Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice

Anomalous appearance of TL (thymus-leukemia) antigens is a characteristic feature of radiation-induced leukemias of C57bl/6 mice. We now report that thymocytes of irradiated C57BL/6 mice express TL antigens long before the development of overt leukemia. Thus, TL is a marker for preleukemic changes o...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1977
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180749/
https://www.ncbi.nlm.nih.gov/pubmed/195001
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collection PubMed
description Anomalous appearance of TL (thymus-leukemia) antigens is a characteristic feature of radiation-induced leukemias of C57bl/6 mice. We now report that thymocytes of irradiated C57BL/6 mice express TL antigens long before the development of overt leukemia. Thus, TL is a marker for preleukemic changes occurring during radiation leukemogenesis. Low levels of murine leukemia virus (MuLV)-related antigens are also detected on preleukemic thymocytes. Comparative tests on individual mice show no direct correlation between TL and MuLV antigen expression.
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spelling pubmed-21807492008-04-17 Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice J Exp Med Articles Anomalous appearance of TL (thymus-leukemia) antigens is a characteristic feature of radiation-induced leukemias of C57bl/6 mice. We now report that thymocytes of irradiated C57BL/6 mice express TL antigens long before the development of overt leukemia. Thus, TL is a marker for preleukemic changes occurring during radiation leukemogenesis. Low levels of murine leukemia virus (MuLV)-related antigens are also detected on preleukemic thymocytes. Comparative tests on individual mice show no direct correlation between TL and MuLV antigen expression. The Rockefeller University Press 1977-07-01 /pmc/articles/PMC2180749/ /pubmed/195001 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice
title Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice
title_full Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice
title_fullStr Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice
title_full_unstemmed Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice
title_short Preleukemic expression of TL antigens in x-irradiated C57BL/6 mice
title_sort preleukemic expression of tl antigens in x-irradiated c57bl/6 mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180749/
https://www.ncbi.nlm.nih.gov/pubmed/195001

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