Biosynthesis of pro-C3, a precursor of the third component of complement

A precusor of the third component of complement, pro-C3, was detected in studies of cell-free synthesis and intracellularly in homogenates of liver tissue cultures. The molecular weight of pro-C3 was indistinguishable from that of intact native C3 secreted in vitro by liver or peritoneal macrophages...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1977
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180790/
https://www.ncbi.nlm.nih.gov/pubmed/561154
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collection PubMed
description A precusor of the third component of complement, pro-C3, was detected in studies of cell-free synthesis and intracellularly in homogenates of liver tissue cultures. The molecular weight of pro-C3 was indistinguishable from that of intact native C3 secreted in vitro by liver or peritoneal macrophages, but its structure was different. Pro- C3 is a single polypeptide chain, whereas C3 secreted by cells in culture consists of two polypeptide chains (mol wt 120,000 and 76,000) linked by disulfide bonds.
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spelling pubmed-21807902008-04-17 Biosynthesis of pro-C3, a precursor of the third component of complement J Exp Med Articles A precusor of the third component of complement, pro-C3, was detected in studies of cell-free synthesis and intracellularly in homogenates of liver tissue cultures. The molecular weight of pro-C3 was indistinguishable from that of intact native C3 secreted in vitro by liver or peritoneal macrophages, but its structure was different. Pro- C3 is a single polypeptide chain, whereas C3 secreted by cells in culture consists of two polypeptide chains (mol wt 120,000 and 76,000) linked by disulfide bonds. The Rockefeller University Press 1977-09-01 /pmc/articles/PMC2180790/ /pubmed/561154 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Biosynthesis of pro-C3, a precursor of the third component of complement
title Biosynthesis of pro-C3, a precursor of the third component of complement
title_full Biosynthesis of pro-C3, a precursor of the third component of complement
title_fullStr Biosynthesis of pro-C3, a precursor of the third component of complement
title_full_unstemmed Biosynthesis of pro-C3, a precursor of the third component of complement
title_short Biosynthesis of pro-C3, a precursor of the third component of complement
title_sort biosynthesis of pro-c3, a precursor of the third component of complement
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180790/
https://www.ncbi.nlm.nih.gov/pubmed/561154

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