Ontogeny of cell-mediated immunity. I. Early development of alloantigen- specific cytotoxic T-cell precursors in postnatal mice

Cytotoxic T-cell precursors have been shown to occur in spleens of 2-3- day-old mice. By 12 days after birth, the cytotoxic T-cell response of spleen cells to alloantigens has reached 23-32% of adult levels. Addition of extra T-helper cells did not permit cytotoxic T-cell development in spleen cells...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1977
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180800/
https://www.ncbi.nlm.nih.gov/pubmed/302309
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collection PubMed
description Cytotoxic T-cell precursors have been shown to occur in spleens of 2-3- day-old mice. By 12 days after birth, the cytotoxic T-cell response of spleen cells to alloantigens has reached 23-32% of adult levels. Addition of extra T-helper cells did not permit cytotoxic T-cell development in spleen cells from newborn to 2-day-old mice suggesting either a lack of precursors or suppression of precursors. The ontogeny of cell-mediated immune functions has thus been shown to correlate well with other work on the development of humoral immunity, accessory cells, and graft versus host reactivity.
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spelling pubmed-21808002008-04-17 Ontogeny of cell-mediated immunity. I. Early development of alloantigen- specific cytotoxic T-cell precursors in postnatal mice J Exp Med Articles Cytotoxic T-cell precursors have been shown to occur in spleens of 2-3- day-old mice. By 12 days after birth, the cytotoxic T-cell response of spleen cells to alloantigens has reached 23-32% of adult levels. Addition of extra T-helper cells did not permit cytotoxic T-cell development in spleen cells from newborn to 2-day-old mice suggesting either a lack of precursors or suppression of precursors. The ontogeny of cell-mediated immune functions has thus been shown to correlate well with other work on the development of humoral immunity, accessory cells, and graft versus host reactivity. The Rockefeller University Press 1977-09-01 /pmc/articles/PMC2180800/ /pubmed/302309 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Ontogeny of cell-mediated immunity. I. Early development of alloantigen- specific cytotoxic T-cell precursors in postnatal mice
title Ontogeny of cell-mediated immunity. I. Early development of alloantigen- specific cytotoxic T-cell precursors in postnatal mice
title_full Ontogeny of cell-mediated immunity. I. Early development of alloantigen- specific cytotoxic T-cell precursors in postnatal mice
title_fullStr Ontogeny of cell-mediated immunity. I. Early development of alloantigen- specific cytotoxic T-cell precursors in postnatal mice
title_full_unstemmed Ontogeny of cell-mediated immunity. I. Early development of alloantigen- specific cytotoxic T-cell precursors in postnatal mice
title_short Ontogeny of cell-mediated immunity. I. Early development of alloantigen- specific cytotoxic T-cell precursors in postnatal mice
title_sort ontogeny of cell-mediated immunity. i. early development of alloantigen- specific cytotoxic t-cell precursors in postnatal mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180800/
https://www.ncbi.nlm.nih.gov/pubmed/302309

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