Resistance genes to murine leukemia in the I immune response gene region of the H-2 complex

A resistance locus to leukemogenesis in mice by A-RadLV (a variant of the radiation leukemia virus) is described. This locus, Rrv-1, was mapped to subregions I-A, I-B, and I-J of the H-2 complex. It is suggested that Rrv-1 may be in complementation with a second locus to the right of it, between Rrv...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1977
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180826/
https://www.ncbi.nlm.nih.gov/pubmed/197197
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description A resistance locus to leukemogenesis in mice by A-RadLV (a variant of the radiation leukemia virus) is described. This locus, Rrv-1, was mapped to subregions I-A, I-B, and I-J of the H-2 complex. It is suggested that Rrv-1 may be in complementation with a second locus to the right of it, between Rrv-1 and H-2D. This localization and the complementation of the two loci for resistance are characteristics similar to Ir genes, and indicate a possible relationship between the genetic regulation of immune responsiveness and susceptibility to leukemia.
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spelling pubmed-21808262008-04-17 Resistance genes to murine leukemia in the I immune response gene region of the H-2 complex J Exp Med Articles A resistance locus to leukemogenesis in mice by A-RadLV (a variant of the radiation leukemia virus) is described. This locus, Rrv-1, was mapped to subregions I-A, I-B, and I-J of the H-2 complex. It is suggested that Rrv-1 may be in complementation with a second locus to the right of it, between Rrv-1 and H-2D. This localization and the complementation of the two loci for resistance are characteristics similar to Ir genes, and indicate a possible relationship between the genetic regulation of immune responsiveness and susceptibility to leukemia. The Rockefeller University Press 1977-10-01 /pmc/articles/PMC2180826/ /pubmed/197197 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Resistance genes to murine leukemia in the I immune response gene region of the H-2 complex
title Resistance genes to murine leukemia in the I immune response gene region of the H-2 complex
title_full Resistance genes to murine leukemia in the I immune response gene region of the H-2 complex
title_fullStr Resistance genes to murine leukemia in the I immune response gene region of the H-2 complex
title_full_unstemmed Resistance genes to murine leukemia in the I immune response gene region of the H-2 complex
title_short Resistance genes to murine leukemia in the I immune response gene region of the H-2 complex
title_sort resistance genes to murine leukemia in the i immune response gene region of the h-2 complex
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180826/
https://www.ncbi.nlm.nih.gov/pubmed/197197

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