Blocking of in vitro and in vivo susceptibility to mouse hepatitis virus

By pretreatment with concanavalin A (Con A) both in vivo and in vitro genetically susceptible mice and their cultured macrophages have been converted to animals and cells which are phenotypically resistant to mouse hepatitus virus (MHV). Con A at 1.0 mg/mouse decreased the mortality from 100% to les...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1977
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180971/
https://www.ncbi.nlm.nih.gov/pubmed/925609
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description By pretreatment with concanavalin A (Con A) both in vivo and in vitro genetically susceptible mice and their cultured macrophages have been converted to animals and cells which are phenotypically resistant to mouse hepatitus virus (MHV). Con A at 1.0 mg/mouse decreased the mortality from 100% to less than 40% by inducing a prominent inflammatory response, increasing the number of macrophages in the virus inoculation site, and producing a population of macrophages not uniformly susceptible to the virus. In addition, mediators derived from Con A-treated spleen cells conferred resistance to normally susceptible syngeneic macrophages to 100 TCID50 of MHV.
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spelling pubmed-21809712008-04-17 Blocking of in vitro and in vivo susceptibility to mouse hepatitis virus J Exp Med Articles By pretreatment with concanavalin A (Con A) both in vivo and in vitro genetically susceptible mice and their cultured macrophages have been converted to animals and cells which are phenotypically resistant to mouse hepatitus virus (MHV). Con A at 1.0 mg/mouse decreased the mortality from 100% to less than 40% by inducing a prominent inflammatory response, increasing the number of macrophages in the virus inoculation site, and producing a population of macrophages not uniformly susceptible to the virus. In addition, mediators derived from Con A-treated spleen cells conferred resistance to normally susceptible syngeneic macrophages to 100 TCID50 of MHV. The Rockefeller University Press 1977-11-01 /pmc/articles/PMC2180971/ /pubmed/925609 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Blocking of in vitro and in vivo susceptibility to mouse hepatitis virus
title Blocking of in vitro and in vivo susceptibility to mouse hepatitis virus
title_full Blocking of in vitro and in vivo susceptibility to mouse hepatitis virus
title_fullStr Blocking of in vitro and in vivo susceptibility to mouse hepatitis virus
title_full_unstemmed Blocking of in vitro and in vivo susceptibility to mouse hepatitis virus
title_short Blocking of in vitro and in vivo susceptibility to mouse hepatitis virus
title_sort blocking of in vitro and in vivo susceptibility to mouse hepatitis virus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180971/
https://www.ncbi.nlm.nih.gov/pubmed/925609

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