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Quantitative studies on the precursors of cytotoxic lymphocytes. III. The lineage of memory cells

In the course of a mixed lymphocyte culture, memory cells are produced which can give rise to a large secondary cytotoxic lymphocyte response on reexposure to the sensitizing alloantigen. We have studied the lineage of these memory cells using a clonal assay for precursors of cytotoxic T lymphocytes...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1977
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180972/
https://www.ncbi.nlm.nih.gov/pubmed/144768
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description In the course of a mixed lymphocyte culture, memory cells are produced which can give rise to a large secondary cytotoxic lymphocyte response on reexposure to the sensitizing alloantigen. We have studied the lineage of these memory cells using a clonal assay for precursors of cytotoxic T lymphocytes (CLP). Our data provide conclusive evidence that individual CLP, upon stimulation with alloantigens, gives rise to clones which contain memory cells of the same specificity as the CLP. Only half of the clones that responded in the primary stimulation could be reactivated upon exposure to the original priming alloantigen.
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spelling pubmed-21809722008-04-17 Quantitative studies on the precursors of cytotoxic lymphocytes. III. The lineage of memory cells J Exp Med Articles In the course of a mixed lymphocyte culture, memory cells are produced which can give rise to a large secondary cytotoxic lymphocyte response on reexposure to the sensitizing alloantigen. We have studied the lineage of these memory cells using a clonal assay for precursors of cytotoxic T lymphocytes (CLP). Our data provide conclusive evidence that individual CLP, upon stimulation with alloantigens, gives rise to clones which contain memory cells of the same specificity as the CLP. Only half of the clones that responded in the primary stimulation could be reactivated upon exposure to the original priming alloantigen. The Rockefeller University Press 1977-11-01 /pmc/articles/PMC2180972/ /pubmed/144768 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Quantitative studies on the precursors of cytotoxic lymphocytes. III. The lineage of memory cells
title Quantitative studies on the precursors of cytotoxic lymphocytes. III. The lineage of memory cells
title_full Quantitative studies on the precursors of cytotoxic lymphocytes. III. The lineage of memory cells
title_fullStr Quantitative studies on the precursors of cytotoxic lymphocytes. III. The lineage of memory cells
title_full_unstemmed Quantitative studies on the precursors of cytotoxic lymphocytes. III. The lineage of memory cells
title_short Quantitative studies on the precursors of cytotoxic lymphocytes. III. The lineage of memory cells
title_sort quantitative studies on the precursors of cytotoxic lymphocytes. iii. the lineage of memory cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2180972/
https://www.ncbi.nlm.nih.gov/pubmed/144768