B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production

The role played by macrophages in two effects of lipopolysaccharide (LPS) on the immune system of the mouse-substitution for helper T cells and induction of B-cell mitosis-has been investigated. C3H/HeJ mice are unresponsive and do not produce (as other strains do) antibody to 2,4,6- trinitrophenol...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1977
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2181908/
https://www.ncbi.nlm.nih.gov/pubmed/303685
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collection PubMed
description The role played by macrophages in two effects of lipopolysaccharide (LPS) on the immune system of the mouse-substitution for helper T cells and induction of B-cell mitosis-has been investigated. C3H/HeJ mice are unresponsive and do not produce (as other strains do) antibody to 2,4,6- trinitrophenol (TNP) conjugated with autologous mouse erythrocytes (MRBC-TNP) in the presence of LPS. We found that C3H/HeJ spleen cells produce antibody to MRBC-TNP when (a) LPS and macrophages from LPS- responsive C3HeB/FeJ mice or (b) tumor necrosis serum ([TNS] induced by LPS in responsive mice) are added. The mitotic response was not restored. The findings suggest that adjuvanticity and mitogenicity represent distinct pathways of B-cell activation by LPS, subject to different regulatory mechanisms.
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spelling pubmed-21819082008-04-17 B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production J Exp Med Articles The role played by macrophages in two effects of lipopolysaccharide (LPS) on the immune system of the mouse-substitution for helper T cells and induction of B-cell mitosis-has been investigated. C3H/HeJ mice are unresponsive and do not produce (as other strains do) antibody to 2,4,6- trinitrophenol (TNP) conjugated with autologous mouse erythrocytes (MRBC-TNP) in the presence of LPS. We found that C3H/HeJ spleen cells produce antibody to MRBC-TNP when (a) LPS and macrophages from LPS- responsive C3HeB/FeJ mice or (b) tumor necrosis serum ([TNS] induced by LPS in responsive mice) are added. The mitotic response was not restored. The findings suggest that adjuvanticity and mitogenicity represent distinct pathways of B-cell activation by LPS, subject to different regulatory mechanisms. The Rockefeller University Press 1977-12-01 /pmc/articles/PMC2181908/ /pubmed/303685 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production
title B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production
title_full B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production
title_fullStr B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production
title_full_unstemmed B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production
title_short B-cell activation by lipopolysaccharide. Distinct pathways for induction of mitosis and antibody production
title_sort b-cell activation by lipopolysaccharide. distinct pathways for induction of mitosis and antibody production
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2181908/
https://www.ncbi.nlm.nih.gov/pubmed/303685

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