Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell

Small amounts of PGE inhibit mitogen-induced [3H]thymidine incorporation in human peripheral lymphocytes. The 50% inhibitory concentration is approximately 10(-7) M, and this is reduced to approximately 10(-8) M when endogenous PGE production is blocked. PGE inhibits PHA- and Con A-stimulated cultur...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1977
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2181914/
https://www.ncbi.nlm.nih.gov/pubmed/411876
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description Small amounts of PGE inhibit mitogen-induced [3H]thymidine incorporation in human peripheral lymphocytes. The 50% inhibitory concentration is approximately 10(-7) M, and this is reduced to approximately 10(-8) M when endogenous PGE production is blocked. PGE inhibits PHA- and Con A-stimulated cultures much better than PWM cultures, suggesting a differential effect of PGE on T-cell vs. B-cell function. In vitro blockade of PG synthesis results in approximately 50% increase in [3H]thymidine incorporation in PHA cultures. PGE is produced endogenously in PHA cultures by glass adherent suppressor cells.
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spelling pubmed-21819142008-04-17 Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell J Exp Med Articles Small amounts of PGE inhibit mitogen-induced [3H]thymidine incorporation in human peripheral lymphocytes. The 50% inhibitory concentration is approximately 10(-7) M, and this is reduced to approximately 10(-8) M when endogenous PGE production is blocked. PGE inhibits PHA- and Con A-stimulated cultures much better than PWM cultures, suggesting a differential effect of PGE on T-cell vs. B-cell function. In vitro blockade of PG synthesis results in approximately 50% increase in [3H]thymidine incorporation in PHA cultures. PGE is produced endogenously in PHA cultures by glass adherent suppressor cells. The Rockefeller University Press 1977-12-01 /pmc/articles/PMC2181914/ /pubmed/411876 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell
title Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell
title_full Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell
title_fullStr Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell
title_full_unstemmed Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell
title_short Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell
title_sort suppression of human t-cell mitogenesis by prostaglandin. existence of a prostaglandin-producing suppressor cell
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2181914/
https://www.ncbi.nlm.nih.gov/pubmed/411876

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