High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction

In the rat , ligation of the bile duct induces a rapid and progressive elevation of the IgA levels in serum. The increase is about 4-fold at 1 h, 15-fold at 1 day, and 30-fold at 1 wk after ligation. The additional IgA is of the secretory type. Free secretory component also appears in serum after bi...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1978
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184194/
https://www.ncbi.nlm.nih.gov/pubmed/632751
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description In the rat , ligation of the bile duct induces a rapid and progressive elevation of the IgA levels in serum. The increase is about 4-fold at 1 h, 15-fold at 1 day, and 30-fold at 1 wk after ligation. The additional IgA is of the secretory type. Free secretory component also appears in serum after bile duct obstruction; it does not continue to increase and occasionally disappears from serum after prolonged ligation. The increase in serum IgA levels is selective. These changes are totally reversible if the bile duct is reopened at 1 day after ligature. These findings confirm the role of the rat liver in the transfer of circulating IgA into the bile.
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spelling pubmed-21841942008-04-17 High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction J Exp Med Articles In the rat , ligation of the bile duct induces a rapid and progressive elevation of the IgA levels in serum. The increase is about 4-fold at 1 h, 15-fold at 1 day, and 30-fold at 1 wk after ligation. The additional IgA is of the secretory type. Free secretory component also appears in serum after bile duct obstruction; it does not continue to increase and occasionally disappears from serum after prolonged ligation. The increase in serum IgA levels is selective. These changes are totally reversible if the bile duct is reopened at 1 day after ligature. These findings confirm the role of the rat liver in the transfer of circulating IgA into the bile. The Rockefeller University Press 1978-03-01 /pmc/articles/PMC2184194/ /pubmed/632751 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction
title High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction
title_full High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction
title_fullStr High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction
title_full_unstemmed High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction
title_short High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction
title_sort high levels of secretory iga and free secretory component in the serum of rats with bile duct obstruction
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184194/
https://www.ncbi.nlm.nih.gov/pubmed/632751

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