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Cytotoxic T cells recognize male antigen and H-2 as distinct entities

XX cells from XX/XY hemopoietic chimeras do not express male determinants in a way to render them either stimulators or targets for male-specific cytotoxic lymphocytes. XX- but not XY-responder T cells from chimeras can be activated to lyse allogeneic male target cells; T cells from normal XX mice d...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1978
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184235/
https://www.ncbi.nlm.nih.gov/pubmed/306412
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collection PubMed
description XX cells from XX/XY hemopoietic chimeras do not express male determinants in a way to render them either stimulators or targets for male-specific cytotoxic lymphocytes. XX- but not XY-responder T cells from chimeras can be activated to lyse allogeneic male target cells; T cells from normal XX mice depleted of alloreactive T cells, however, cannot be sensitized to lyse allogeneic XY targets. The results imply that T cells recognize the Y-antigen and H-2 as distinct entities, and that in chimeras, they acquire the potential to react against allogeneic XY cells.
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spelling pubmed-21842352008-04-17 Cytotoxic T cells recognize male antigen and H-2 as distinct entities J Exp Med Articles XX cells from XX/XY hemopoietic chimeras do not express male determinants in a way to render them either stimulators or targets for male-specific cytotoxic lymphocytes. XX- but not XY-responder T cells from chimeras can be activated to lyse allogeneic male target cells; T cells from normal XX mice depleted of alloreactive T cells, however, cannot be sensitized to lyse allogeneic XY targets. The results imply that T cells recognize the Y-antigen and H-2 as distinct entities, and that in chimeras, they acquire the potential to react against allogeneic XY cells. The Rockefeller University Press 1978-04-01 /pmc/articles/PMC2184235/ /pubmed/306412 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Cytotoxic T cells recognize male antigen and H-2 as distinct entities
title Cytotoxic T cells recognize male antigen and H-2 as distinct entities
title_full Cytotoxic T cells recognize male antigen and H-2 as distinct entities
title_fullStr Cytotoxic T cells recognize male antigen and H-2 as distinct entities
title_full_unstemmed Cytotoxic T cells recognize male antigen and H-2 as distinct entities
title_short Cytotoxic T cells recognize male antigen and H-2 as distinct entities
title_sort cytotoxic t cells recognize male antigen and h-2 as distinct entities
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184235/
https://www.ncbi.nlm.nih.gov/pubmed/306412