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Lung tumor-associated derepressed alloantigen coded for by the K region of the H-2 major histocompatibility complex

Transplacental induction of lung tumors in C3HfeB/HeN (C3Hf) strain mice can be readily achieved with the carcinogen 1-ethyl-1-nitrosourea. Several of these tumors express, as a tumor-associated transplantation antigen (TATA), a normal tissue alloantigen present in strain A and C3H/HeN (C3H) mice. I...

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Autores principales: Gipson, TG, Imamura, M, Conliffe, MA, Martin, WJ
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1978
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184264/
https://www.ncbi.nlm.nih.gov/pubmed/418138
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author Gipson, TG
Imamura, M
Conliffe, MA
Martin, WJ
author_facet Gipson, TG
Imamura, M
Conliffe, MA
Martin, WJ
author_sort Gipson, TG
collection PubMed
description Transplacental induction of lung tumors in C3HfeB/HeN (C3Hf) strain mice can be readily achieved with the carcinogen 1-ethyl-1-nitrosourea. Several of these tumors express, as a tumor-associated transplantation antigen (TATA), a normal tissue alloantigen present in strain A and C3H/HeN (C3H) mice. In the present study it was shown that the tumor-associated alloantigen on the C3Hf-derived lung tumor 85 was present in all mice of H-2(a) and H-2(k) haplotypes tested and in CBA (532) strain mice (H-2(ka) haplotype). Studies using congenic-resistant and recombinant strains of mice indicated that the genetic locus controlling the expression of this antigen was either within or to the left of the H-2K region of the major histocompatibility complex (MHC). Thus the antigen was expressed in B10.A (4R) mice (kkbbbb MHC haplotype) but not in B10 (bbbbbb) or B10.AQR mice (qkkddd). The antigen was expressed in all tissues tested of C3H and A strain mice. It was not detected on any tissue tested including embryo tissue of C3Hf mice or mice of MHC haplotype other than H-2(k) or H-2(a). Because C3Hf strain mice were originally derived from C3H strain mice (H-2(k)), the MHC haplotype of C3Hf mice has been provisionally designated H-2(kb). The finding of a tumor-associated change in the expression of a H-2K region-coded antigen is consistent with the concept that MHC-coded antigens may act as targets for immunological surveillance of tumors.
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spelling pubmed-21842642008-04-17 Lung tumor-associated derepressed alloantigen coded for by the K region of the H-2 major histocompatibility complex Gipson, TG Imamura, M Conliffe, MA Martin, WJ J Exp Med Articles Transplacental induction of lung tumors in C3HfeB/HeN (C3Hf) strain mice can be readily achieved with the carcinogen 1-ethyl-1-nitrosourea. Several of these tumors express, as a tumor-associated transplantation antigen (TATA), a normal tissue alloantigen present in strain A and C3H/HeN (C3H) mice. In the present study it was shown that the tumor-associated alloantigen on the C3Hf-derived lung tumor 85 was present in all mice of H-2(a) and H-2(k) haplotypes tested and in CBA (532) strain mice (H-2(ka) haplotype). Studies using congenic-resistant and recombinant strains of mice indicated that the genetic locus controlling the expression of this antigen was either within or to the left of the H-2K region of the major histocompatibility complex (MHC). Thus the antigen was expressed in B10.A (4R) mice (kkbbbb MHC haplotype) but not in B10 (bbbbbb) or B10.AQR mice (qkkddd). The antigen was expressed in all tissues tested of C3H and A strain mice. It was not detected on any tissue tested including embryo tissue of C3Hf mice or mice of MHC haplotype other than H-2(k) or H-2(a). Because C3Hf strain mice were originally derived from C3H strain mice (H-2(k)), the MHC haplotype of C3Hf mice has been provisionally designated H-2(kb). The finding of a tumor-associated change in the expression of a H-2K region-coded antigen is consistent with the concept that MHC-coded antigens may act as targets for immunological surveillance of tumors. The Rockefeller University Press 1978-05-01 /pmc/articles/PMC2184264/ /pubmed/418138 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Gipson, TG
Imamura, M
Conliffe, MA
Martin, WJ
Lung tumor-associated derepressed alloantigen coded for by the K region of the H-2 major histocompatibility complex
title Lung tumor-associated derepressed alloantigen coded for by the K region of the H-2 major histocompatibility complex
title_full Lung tumor-associated derepressed alloantigen coded for by the K region of the H-2 major histocompatibility complex
title_fullStr Lung tumor-associated derepressed alloantigen coded for by the K region of the H-2 major histocompatibility complex
title_full_unstemmed Lung tumor-associated derepressed alloantigen coded for by the K region of the H-2 major histocompatibility complex
title_short Lung tumor-associated derepressed alloantigen coded for by the K region of the H-2 major histocompatibility complex
title_sort lung tumor-associated derepressed alloantigen coded for by the k region of the h-2 major histocompatibility complex
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184264/
https://www.ncbi.nlm.nih.gov/pubmed/418138
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