T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells

We have determined the Ly phenotype of the T lymphocytes which proliferate in response to mutant H-2K and H-2D alloantigens in primary mixed lymphocyte culture. Responder T cells proliferating in reciprocal cultures of H-2d(KdDd) and H-2da(KdDda) lymphocytes were typed Ly 2+ through selective deplet...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1978
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184279/
https://www.ncbi.nlm.nih.gov/pubmed/148487
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description We have determined the Ly phenotype of the T lymphocytes which proliferate in response to mutant H-2K and H-2D alloantigens in primary mixed lymphocyte culture. Responder T cells proliferating in reciprocal cultures of H-2d(KdDd) and H-2da(KdDda) lymphocytes were typed Ly 2+ through selective depletion with specific alloantiserum plus complement. Further, B6-Ly 1a lymphocytes proliferating in response to B6-H-2ba and B6-H-2bf stimulators were typed as Ly 1+2+ through similar analysis. These results are discussed with regard to their impact on views of lymphocyte differentiation and factors determining the identity of alloreactive lymphocytes.
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spelling pubmed-21842792008-04-17 T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells J Exp Med Articles We have determined the Ly phenotype of the T lymphocytes which proliferate in response to mutant H-2K and H-2D alloantigens in primary mixed lymphocyte culture. Responder T cells proliferating in reciprocal cultures of H-2d(KdDd) and H-2da(KdDda) lymphocytes were typed Ly 2+ through selective depletion with specific alloantiserum plus complement. Further, B6-Ly 1a lymphocytes proliferating in response to B6-H-2ba and B6-H-2bf stimulators were typed as Ly 1+2+ through similar analysis. These results are discussed with regard to their impact on views of lymphocyte differentiation and factors determining the identity of alloreactive lymphocytes. The Rockefeller University Press 1978-05-01 /pmc/articles/PMC2184279/ /pubmed/148487 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells
title T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells
title_full T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells
title_fullStr T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells
title_full_unstemmed T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells
title_short T-lymphocyte response to H-2 mutants. I. Proliferation is dependent on Ly 1+2+ cells
title_sort t-lymphocyte response to h-2 mutants. i. proliferation is dependent on ly 1+2+ cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184279/
https://www.ncbi.nlm.nih.gov/pubmed/148487

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