Human granulocyte generation of hydroxyl radical

Human granulocytes were capable of oxidizing 2-keto-4 thiomethylbutyric acid to ethylene during phagocytosis or membrane perturbation. The reaction required hydrogen peroxide and superoxide and in addition was inhibited by various hydroxyl radical (OH) scavengers. These observations represent direct...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1978
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184490/
https://www.ncbi.nlm.nih.gov/pubmed/203651
_version_ 1782145683867828224
collection PubMed
description Human granulocytes were capable of oxidizing 2-keto-4 thiomethylbutyric acid to ethylene during phagocytosis or membrane perturbation. The reaction required hydrogen peroxide and superoxide and in addition was inhibited by various hydroxyl radical (OH) scavengers. These observations represent direct evidence for the generation of OH by human granulocytes. Further, inhibition of ethylene generation by azide and cyanide suggests that OH generation in granulocytes may be linked to myeloperoxidase.
format Text
id pubmed-2184490
institution National Center for Biotechnology Information
language English
publishDate 1978
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21844902008-04-17 Human granulocyte generation of hydroxyl radical J Exp Med Articles Human granulocytes were capable of oxidizing 2-keto-4 thiomethylbutyric acid to ethylene during phagocytosis or membrane perturbation. The reaction required hydrogen peroxide and superoxide and in addition was inhibited by various hydroxyl radical (OH) scavengers. These observations represent direct evidence for the generation of OH by human granulocytes. Further, inhibition of ethylene generation by azide and cyanide suggests that OH generation in granulocytes may be linked to myeloperoxidase. The Rockefeller University Press 1978-02-01 /pmc/articles/PMC2184490/ /pubmed/203651 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Human granulocyte generation of hydroxyl radical
title Human granulocyte generation of hydroxyl radical
title_full Human granulocyte generation of hydroxyl radical
title_fullStr Human granulocyte generation of hydroxyl radical
title_full_unstemmed Human granulocyte generation of hydroxyl radical
title_short Human granulocyte generation of hydroxyl radical
title_sort human granulocyte generation of hydroxyl radical
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184490/
https://www.ncbi.nlm.nih.gov/pubmed/203651

Ejemplares similares