Differential cyclophosphamide sensitivity of precursor cells in allogeneic and H-2 restricted cytotoxic responses

Spleen cells from cyclophosphamide-treated mice responded in vitro to allogeneic stimulator cells but not to TNP-coupled syngeneic spleen cells. Similarly, cells from female mice, primed in vivo with syngeneic male cells, could not respond in vitro to male spleen cell stimulation if the mice were pr...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184736/
https://www.ncbi.nlm.nih.gov/pubmed/153933
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collection PubMed
description Spleen cells from cyclophosphamide-treated mice responded in vitro to allogeneic stimulator cells but not to TNP-coupled syngeneic spleen cells. Similarly, cells from female mice, primed in vivo with syngeneic male cells, could not respond in vitro to male spleen cell stimulation if the mice were pretreated with cyclophosphamide. These results suggest that the precursor cells for H-2-restricted cytotoxic responses belong to a different T-cell subpopulation than the precursor cells for allogeneic responses.
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spelling pubmed-21847362008-04-17 Differential cyclophosphamide sensitivity of precursor cells in allogeneic and H-2 restricted cytotoxic responses J Exp Med Articles Spleen cells from cyclophosphamide-treated mice responded in vitro to allogeneic stimulator cells but not to TNP-coupled syngeneic spleen cells. Similarly, cells from female mice, primed in vivo with syngeneic male cells, could not respond in vitro to male spleen cell stimulation if the mice were pretreated with cyclophosphamide. These results suggest that the precursor cells for H-2-restricted cytotoxic responses belong to a different T-cell subpopulation than the precursor cells for allogeneic responses. The Rockefeller University Press 1979-01-01 /pmc/articles/PMC2184736/ /pubmed/153933 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Differential cyclophosphamide sensitivity of precursor cells in allogeneic and H-2 restricted cytotoxic responses
title Differential cyclophosphamide sensitivity of precursor cells in allogeneic and H-2 restricted cytotoxic responses
title_full Differential cyclophosphamide sensitivity of precursor cells in allogeneic and H-2 restricted cytotoxic responses
title_fullStr Differential cyclophosphamide sensitivity of precursor cells in allogeneic and H-2 restricted cytotoxic responses
title_full_unstemmed Differential cyclophosphamide sensitivity of precursor cells in allogeneic and H-2 restricted cytotoxic responses
title_short Differential cyclophosphamide sensitivity of precursor cells in allogeneic and H-2 restricted cytotoxic responses
title_sort differential cyclophosphamide sensitivity of precursor cells in allogeneic and h-2 restricted cytotoxic responses
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184736/
https://www.ncbi.nlm.nih.gov/pubmed/153933

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