Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging

The rate of capping and shedding of cross-linked surface immunoglobulins (SIg) was slower in old Lewis rats (greater than 24 mo) than in young Lewis rats (3-4 mo). Analysis of spleen cell populations with the fluorescence-activated cell sorter indicated that with aging there was a loss of cells with...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184810/
https://www.ncbi.nlm.nih.gov/pubmed/310864
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collection PubMed
description The rate of capping and shedding of cross-linked surface immunoglobulins (SIg) was slower in old Lewis rats (greater than 24 mo) than in young Lewis rats (3-4 mo). Analysis of spleen cell populations with the fluorescence-activated cell sorter indicated that with aging there was a loss of cells with a high density of SIg. Cells with the highest density of SIg capped and shed cross-linked SIg faster than cells with a low density of SIg. The alteration in density of SIg may account for the difference in capping kinetics. Colchicine treatment increased the rate of capping of lymphocytes from young animals, but had no effect on the capping kinetics of lymphocytes from old animals.
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spelling pubmed-21848102008-04-17 Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging J Exp Med Articles The rate of capping and shedding of cross-linked surface immunoglobulins (SIg) was slower in old Lewis rats (greater than 24 mo) than in young Lewis rats (3-4 mo). Analysis of spleen cell populations with the fluorescence-activated cell sorter indicated that with aging there was a loss of cells with a high density of SIg. Cells with the highest density of SIg capped and shed cross-linked SIg faster than cells with a low density of SIg. The alteration in density of SIg may account for the difference in capping kinetics. Colchicine treatment increased the rate of capping of lymphocytes from young animals, but had no effect on the capping kinetics of lymphocytes from old animals. The Rockefeller University Press 1979-02-01 /pmc/articles/PMC2184810/ /pubmed/310864 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging
title Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging
title_full Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging
title_fullStr Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging
title_full_unstemmed Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging
title_short Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging
title_sort density of surface immunoglobulin and capping on rat b lymphocytes. i. changes with aging
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184810/
https://www.ncbi.nlm.nih.gov/pubmed/310864

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