HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus

We have investigated elements of the genetic control of human in vitro cytotoxic T-cell responses to influenza virus-infected autologous cells by studies of a large family. The pattern of virus-immune cytotoxicity among siblings demonstrated T-cell recognition of influenza virus predominantly (great...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184821/
https://www.ncbi.nlm.nih.gov/pubmed/311809
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description We have investigated elements of the genetic control of human in vitro cytotoxic T-cell responses to influenza virus-infected autologous cells by studies of a large family. The pattern of virus-immune cytotoxicity among siblings demonstrated T-cell recognition of influenza virus predominantly (greater than 90%) in association with determinants which are coded by genes linked to HLA (P less than 0.0002). Many family members consistently generated cytotoxic activity against influenza predominantly in association with antigens coded by genes of only one of their HLA haplotypes. Such haplotype preferences were consistent among HLA-identical siblings, indicating that the specificity of the T- cell response to influenza virus in association with HLA-A and -B antigens is controlled by genes linked to HLA.
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spelling pubmed-21848212008-04-17 HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus J Exp Med Articles We have investigated elements of the genetic control of human in vitro cytotoxic T-cell responses to influenza virus-infected autologous cells by studies of a large family. The pattern of virus-immune cytotoxicity among siblings demonstrated T-cell recognition of influenza virus predominantly (greater than 90%) in association with determinants which are coded by genes linked to HLA (P less than 0.0002). Many family members consistently generated cytotoxic activity against influenza predominantly in association with antigens coded by genes of only one of their HLA haplotypes. Such haplotype preferences were consistent among HLA-identical siblings, indicating that the specificity of the T- cell response to influenza virus in association with HLA-A and -B antigens is controlled by genes linked to HLA. The Rockefeller University Press 1979-03-01 /pmc/articles/PMC2184821/ /pubmed/311809 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus
title HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus
title_full HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus
title_fullStr HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus
title_full_unstemmed HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus
title_short HLA-linked genetic control of the specicity of human cytotoxic T-cell responses to influenza virus
title_sort hla-linked genetic control of the specicity of human cytotoxic t-cell responses to influenza virus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184821/
https://www.ncbi.nlm.nih.gov/pubmed/311809

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