Endotoxin protein is a mitogen and polyclonal activator of human B lymphocytes

Endotoxin protein (EP) has been shown to be a mitogen and polyclonal activator of human peripheral blood lymphocytes. EP stimulates proliferation of B lymphoyctes in the absence of T cells, and this activation is nonspecific by a number of parameters. Additionally, EP mitogenesis, but not polyclonal...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184825/
https://www.ncbi.nlm.nih.gov/pubmed/311814
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collection PubMed
description Endotoxin protein (EP) has been shown to be a mitogen and polyclonal activator of human peripheral blood lymphocytes. EP stimulates proliferation of B lymphoyctes in the absence of T cells, and this activation is nonspecific by a number of parameters. Additionally, EP mitogenesis, but not polyclonal activation, is inhibited in the presence of human serum, suggesting that these events are dissociable. In these studies, EP appears to be equivalent to or better than pokeweed mitogen in stimulating nonspecific antibody production in vitro.
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spelling pubmed-21848252008-04-17 Endotoxin protein is a mitogen and polyclonal activator of human B lymphocytes J Exp Med Articles Endotoxin protein (EP) has been shown to be a mitogen and polyclonal activator of human peripheral blood lymphocytes. EP stimulates proliferation of B lymphoyctes in the absence of T cells, and this activation is nonspecific by a number of parameters. Additionally, EP mitogenesis, but not polyclonal activation, is inhibited in the presence of human serum, suggesting that these events are dissociable. In these studies, EP appears to be equivalent to or better than pokeweed mitogen in stimulating nonspecific antibody production in vitro. The Rockefeller University Press 1979-03-01 /pmc/articles/PMC2184825/ /pubmed/311814 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Endotoxin protein is a mitogen and polyclonal activator of human B lymphocytes
title Endotoxin protein is a mitogen and polyclonal activator of human B lymphocytes
title_full Endotoxin protein is a mitogen and polyclonal activator of human B lymphocytes
title_fullStr Endotoxin protein is a mitogen and polyclonal activator of human B lymphocytes
title_full_unstemmed Endotoxin protein is a mitogen and polyclonal activator of human B lymphocytes
title_short Endotoxin protein is a mitogen and polyclonal activator of human B lymphocytes
title_sort endotoxin protein is a mitogen and polyclonal activator of human b lymphocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184825/
https://www.ncbi.nlm.nih.gov/pubmed/311814

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