Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells

The present studies extend our previous efforts to understand the immunological basis of specifically induced graft-versus-host (GVH) resistance in F1 hybrid rats. Immunization of F1 rats with alloreactive T-cell populations of parental strain origin induces a host-mediated T- cell response which is...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1978
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184917/
https://www.ncbi.nlm.nih.gov/pubmed/78954
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description The present studies extend our previous efforts to understand the immunological basis of specifically induced graft-versus-host (GVH) resistance in F1 hybrid rats. Immunization of F1 rats with alloreactive T-cell populations of parental strain origin induces a host-mediated T- cell response which is specific for anti-major hostocompatibility complex receptors on parental T cells. This protective immunity is rapid in onset and once induced, it provides a highly effective, specific resistance to lethal GVH disease which is radioresistant and can be adoptively transferred to syngeneic recipients.
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spelling pubmed-21849172008-04-17 Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells J Exp Med Articles The present studies extend our previous efforts to understand the immunological basis of specifically induced graft-versus-host (GVH) resistance in F1 hybrid rats. Immunization of F1 rats with alloreactive T-cell populations of parental strain origin induces a host-mediated T- cell response which is specific for anti-major hostocompatibility complex receptors on parental T cells. This protective immunity is rapid in onset and once induced, it provides a highly effective, specific resistance to lethal GVH disease which is radioresistant and can be adoptively transferred to syngeneic recipients. The Rockefeller University Press 1978-07-01 /pmc/articles/PMC2184917/ /pubmed/78954 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells
title Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells
title_full Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells
title_fullStr Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells
title_full_unstemmed Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells
title_short Immunological studies of T-cell receptors. I. Specifically induced resistance to graft-versus-host disease in rats mediated by host T-cell immunity to alloreactive parental T cells
title_sort immunological studies of t-cell receptors. i. specifically induced resistance to graft-versus-host disease in rats mediated by host t-cell immunity to alloreactive parental t cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184917/
https://www.ncbi.nlm.nih.gov/pubmed/78954

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