Regulation of cytotoxic T-cell reactivity to syngeneic tumors by the thymus

Adult thymectomy has been shown to result in the enhanced capacity of splenic T cells to respond to and lyse syngeneic tumor cells in vitro. In addition, T cells from thymectomized mice which kill syngeneic tumor cells do not lyse either normal lymphoid or mitogen-stimulated syngeneic lymphoblast ta...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1978
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184953/
https://www.ncbi.nlm.nih.gov/pubmed/308983
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description Adult thymectomy has been shown to result in the enhanced capacity of splenic T cells to respond to and lyse syngeneic tumor cells in vitro. In addition, T cells from thymectomized mice which kill syngeneic tumor cells do not lyse either normal lymphoid or mitogen-stimulated syngeneic lymphoblast target cells. These findings indicate that the thymus exports a subpopulation of T cells sensitive to adult thymectomy which regulates the generation of cytolytic T cells directed against syngeneic tumor cells.
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spelling pubmed-21849532008-04-17 Regulation of cytotoxic T-cell reactivity to syngeneic tumors by the thymus J Exp Med Articles Adult thymectomy has been shown to result in the enhanced capacity of splenic T cells to respond to and lyse syngeneic tumor cells in vitro. In addition, T cells from thymectomized mice which kill syngeneic tumor cells do not lyse either normal lymphoid or mitogen-stimulated syngeneic lymphoblast target cells. These findings indicate that the thymus exports a subpopulation of T cells sensitive to adult thymectomy which regulates the generation of cytolytic T cells directed against syngeneic tumor cells. The Rockefeller University Press 1978-08-01 /pmc/articles/PMC2184953/ /pubmed/308983 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Regulation of cytotoxic T-cell reactivity to syngeneic tumors by the thymus
title Regulation of cytotoxic T-cell reactivity to syngeneic tumors by the thymus
title_full Regulation of cytotoxic T-cell reactivity to syngeneic tumors by the thymus
title_fullStr Regulation of cytotoxic T-cell reactivity to syngeneic tumors by the thymus
title_full_unstemmed Regulation of cytotoxic T-cell reactivity to syngeneic tumors by the thymus
title_short Regulation of cytotoxic T-cell reactivity to syngeneic tumors by the thymus
title_sort regulation of cytotoxic t-cell reactivity to syngeneic tumors by the thymus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2184953/
https://www.ncbi.nlm.nih.gov/pubmed/308983

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