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Abelson virus-induced lymphomagenesis in mice

The salient facts which have emerged from our study of Abelson virus (MuLV-A)lymphomagenesis in mice are that lymphoma induction is (a) age dependent, (b) virus dose dependent, and (c) under the control of host genes unrelated to other genes known to control murine leukemia (e.g., Fv-1 on Fv-2). Of...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1978
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185010/
https://www.ncbi.nlm.nih.gov/pubmed/702054
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description The salient facts which have emerged from our study of Abelson virus (MuLV-A)lymphomagenesis in mice are that lymphoma induction is (a) age dependent, (b) virus dose dependent, and (c) under the control of host genes unrelated to other genes known to control murine leukemia (e.g., Fv-1 on Fv-2). Of 16 strains tested, only BALB/c and some of its derivative strains showed high sensitivity. Studies from CXB recombinant inbred strains and hybrids between them are interpreted to indicate that BALB/c carries dominant sensitivity alleles at two loci, tentatively designated Av-1 and Av-2, which conferon these mice partial susceptibility to MuLV-A lymphoma induction. In addition, H-2 may play a minor role in determining the susceptibility of mice to MuLV-A, its effect being seen only in mice homozygous for resistance at both Av-1 and Av-2. Virologic studies indicate that the resistance of adult B6 mice is not related to restriction on the helper virus replication, but is specific for the defective transforming virus genome.
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spelling pubmed-21850102008-04-17 Abelson virus-induced lymphomagenesis in mice J Exp Med Articles The salient facts which have emerged from our study of Abelson virus (MuLV-A)lymphomagenesis in mice are that lymphoma induction is (a) age dependent, (b) virus dose dependent, and (c) under the control of host genes unrelated to other genes known to control murine leukemia (e.g., Fv-1 on Fv-2). Of 16 strains tested, only BALB/c and some of its derivative strains showed high sensitivity. Studies from CXB recombinant inbred strains and hybrids between them are interpreted to indicate that BALB/c carries dominant sensitivity alleles at two loci, tentatively designated Av-1 and Av-2, which conferon these mice partial susceptibility to MuLV-A lymphoma induction. In addition, H-2 may play a minor role in determining the susceptibility of mice to MuLV-A, its effect being seen only in mice homozygous for resistance at both Av-1 and Av-2. Virologic studies indicate that the resistance of adult B6 mice is not related to restriction on the helper virus replication, but is specific for the defective transforming virus genome. The Rockefeller University Press 1978-09-01 /pmc/articles/PMC2185010/ /pubmed/702054 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Abelson virus-induced lymphomagenesis in mice
title Abelson virus-induced lymphomagenesis in mice
title_full Abelson virus-induced lymphomagenesis in mice
title_fullStr Abelson virus-induced lymphomagenesis in mice
title_full_unstemmed Abelson virus-induced lymphomagenesis in mice
title_short Abelson virus-induced lymphomagenesis in mice
title_sort abelson virus-induced lymphomagenesis in mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185010/
https://www.ncbi.nlm.nih.gov/pubmed/702054