Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides

The experiments described herein demonstrate the plaque-forming cell response of C3H/HeJ mice can be suppressed by a Boivin type lipopolysaccharide (LPS) and a deproteinized glycolipid. Suppression was observed both in vivo and in vitro, and could be transferred to normal cells in coculture experime...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1978
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185012/
https://www.ncbi.nlm.nih.gov/pubmed/702060
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collection PubMed
description The experiments described herein demonstrate the plaque-forming cell response of C3H/HeJ mice can be suppressed by a Boivin type lipopolysaccharide (LPS) and a deproteinized glycolipid. Suppression was observed both in vivo and in vitro, and could be transferred to normal cells in coculture experiments. This newly discovered effect of LPS in C3H/HeJ mice indicates that the adjuvant and inhibitory action of LPS may be distinct phenomena which are under different genetic regulation. Thus, the C3H/HeJ strain provides a convenient animal model for study of immunosuppression independent of the adjuvant effect.
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spelling pubmed-21850122008-04-17 Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides J Exp Med Articles The experiments described herein demonstrate the plaque-forming cell response of C3H/HeJ mice can be suppressed by a Boivin type lipopolysaccharide (LPS) and a deproteinized glycolipid. Suppression was observed both in vivo and in vitro, and could be transferred to normal cells in coculture experiments. This newly discovered effect of LPS in C3H/HeJ mice indicates that the adjuvant and inhibitory action of LPS may be distinct phenomena which are under different genetic regulation. Thus, the C3H/HeJ strain provides a convenient animal model for study of immunosuppression independent of the adjuvant effect. The Rockefeller University Press 1978-10-01 /pmc/articles/PMC2185012/ /pubmed/702060 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides
title Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides
title_full Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides
title_fullStr Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides
title_full_unstemmed Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides
title_short Suppression of the immune response in C3H/HeJ mice by protein-free lipopolysaccharides
title_sort suppression of the immune response in c3h/hej mice by protein-free lipopolysaccharides
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185012/
https://www.ncbi.nlm.nih.gov/pubmed/702060

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