The first component of complement. A quantitative comparison of its biosynthesis in culture by human epithelial and mesenchymal cells

Epithelial and mesenchymal cells synthesized and secreted all three subcomponents of the first component of complement (C1): C1q, C1r, and C1s. Quantitatively, however, columnar and transitional epithelial cells secreted 400--3,700 times more hemolytically active C1 than monocytes or fibroblasts. On...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1978
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185025/
https://www.ncbi.nlm.nih.gov/pubmed/702057
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description Epithelial and mesenchymal cells synthesized and secreted all three subcomponents of the first component of complement (C1): C1q, C1r, and C1s. Quantitatively, however, columnar and transitional epithelial cells secreted 400--3,700 times more hemolytically active C1 than monocytes or fibroblasts. Only columnar epithelial cells synthesized C1 subcomponents with subunit structures similar to their serum counterparts. Transitional epithelial cells, fibroblasts, and monocytes produced C1q and C1s with subunits of apparent molecular weights larger than reported values. C1r from all cell lines was physiochemically similar to serum C1r.
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spelling pubmed-21850252008-04-17 The first component of complement. A quantitative comparison of its biosynthesis in culture by human epithelial and mesenchymal cells J Exp Med Articles Epithelial and mesenchymal cells synthesized and secreted all three subcomponents of the first component of complement (C1): C1q, C1r, and C1s. Quantitatively, however, columnar and transitional epithelial cells secreted 400--3,700 times more hemolytically active C1 than monocytes or fibroblasts. Only columnar epithelial cells synthesized C1 subcomponents with subunit structures similar to their serum counterparts. Transitional epithelial cells, fibroblasts, and monocytes produced C1q and C1s with subunits of apparent molecular weights larger than reported values. C1r from all cell lines was physiochemically similar to serum C1r. The Rockefeller University Press 1978-10-01 /pmc/articles/PMC2185025/ /pubmed/702057 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The first component of complement. A quantitative comparison of its biosynthesis in culture by human epithelial and mesenchymal cells
title The first component of complement. A quantitative comparison of its biosynthesis in culture by human epithelial and mesenchymal cells
title_full The first component of complement. A quantitative comparison of its biosynthesis in culture by human epithelial and mesenchymal cells
title_fullStr The first component of complement. A quantitative comparison of its biosynthesis in culture by human epithelial and mesenchymal cells
title_full_unstemmed The first component of complement. A quantitative comparison of its biosynthesis in culture by human epithelial and mesenchymal cells
title_short The first component of complement. A quantitative comparison of its biosynthesis in culture by human epithelial and mesenchymal cells
title_sort first component of complement. a quantitative comparison of its biosynthesis in culture by human epithelial and mesenchymal cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185025/
https://www.ncbi.nlm.nih.gov/pubmed/702057

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