Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion

Sequential immunoprecipitation, two-dimensional gel electrophoresis and peptide mapping analyses of B10A(3R), 35S-methionine-labeled, I-EC subregion products were performed. Evidence is presented here for the presence of two structurally homologous, but nonidentical, gene products of the I-EC subreg...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185616/
https://www.ncbi.nlm.nih.gov/pubmed/448292
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collection PubMed
description Sequential immunoprecipitation, two-dimensional gel electrophoresis and peptide mapping analyses of B10A(3R), 35S-methionine-labeled, I-EC subregion products were performed. Evidence is presented here for the presence of two structurally homologous, but nonidentical, gene products of the I-EC subregion. These two Ia molecules are independently immunoprecipitable, identical in molecular size and charge, but differ by approximately equal to 20% in their peptides obtained by partial digestion with Staphylococcus aureus protease V8.
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spelling pubmed-21856162008-04-17 Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion J Exp Med Articles Sequential immunoprecipitation, two-dimensional gel electrophoresis and peptide mapping analyses of B10A(3R), 35S-methionine-labeled, I-EC subregion products were performed. Evidence is presented here for the presence of two structurally homologous, but nonidentical, gene products of the I-EC subregion. These two Ia molecules are independently immunoprecipitable, identical in molecular size and charge, but differ by approximately equal to 20% in their peptides obtained by partial digestion with Staphylococcus aureus protease V8. The Rockefeller University Press 1979-07-01 /pmc/articles/PMC2185616/ /pubmed/448292 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion
title Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion
title_full Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion
title_fullStr Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion
title_full_unstemmed Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion
title_short Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion
title_sort evidence for two homologous, but nonidentical, ia molecules determined by the i-ec subregion
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185616/
https://www.ncbi.nlm.nih.gov/pubmed/448292

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