Reversal of nzb/nzw disease with total lymphoid irradiation

NZB/NZW mice spontaneously exhibit autoimmune disease similar to that seen in human systemic lupus erythematosus (SLE). We demonstrated that total lymphoid irradiation (TLI) reversed well expressed disease in 6- mo-old NZB/NZW females with a prolongation in survival, decrease in proteinuria, and dec...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185621/
https://www.ncbi.nlm.nih.gov/pubmed/313431
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collection PubMed
description NZB/NZW mice spontaneously exhibit autoimmune disease similar to that seen in human systemic lupus erythematosus (SLE). We demonstrated that total lymphoid irradiation (TLI) reversed well expressed disease in 6- mo-old NZB/NZW females with a prolongation in survival, decrease in proteinuria, and decrease in anti-DNA antibodies as compared to control animals. Few side effects were observed in the treated group. TLI also prolonged survival in animals with advanced renal disease. These findings suggest that TLI may have application to the treatment of human SLE.
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spelling pubmed-21856212008-04-17 Reversal of nzb/nzw disease with total lymphoid irradiation J Exp Med Articles NZB/NZW mice spontaneously exhibit autoimmune disease similar to that seen in human systemic lupus erythematosus (SLE). We demonstrated that total lymphoid irradiation (TLI) reversed well expressed disease in 6- mo-old NZB/NZW females with a prolongation in survival, decrease in proteinuria, and decrease in anti-DNA antibodies as compared to control animals. Few side effects were observed in the treated group. TLI also prolonged survival in animals with advanced renal disease. These findings suggest that TLI may have application to the treatment of human SLE. The Rockefeller University Press 1979-08-01 /pmc/articles/PMC2185621/ /pubmed/313431 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Reversal of nzb/nzw disease with total lymphoid irradiation
title Reversal of nzb/nzw disease with total lymphoid irradiation
title_full Reversal of nzb/nzw disease with total lymphoid irradiation
title_fullStr Reversal of nzb/nzw disease with total lymphoid irradiation
title_full_unstemmed Reversal of nzb/nzw disease with total lymphoid irradiation
title_short Reversal of nzb/nzw disease with total lymphoid irradiation
title_sort reversal of nzb/nzw disease with total lymphoid irradiation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185621/
https://www.ncbi.nlm.nih.gov/pubmed/313431

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