The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells

The proliferative response of mouse B lymphocytes induced by Fc fragments was found to be dependent upon an adherent cell population. The adherent cell is esterase positive, irradiation resistant, and not susceptible to lysis by anti-thymus serum and complement. The mechanism(s) by which Fc fragment...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185629/
https://www.ncbi.nlm.nih.gov/pubmed/458375
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collection PubMed
description The proliferative response of mouse B lymphocytes induced by Fc fragments was found to be dependent upon an adherent cell population. The adherent cell is esterase positive, irradiation resistant, and not susceptible to lysis by anti-thymus serum and complement. The mechanism(s) by which Fc fragments induce B-cell proliferation could be the result of the interaction of Fc with both B cells and adherent cells or with adherent cells which then release factors that trigger the B cells to proliferate. Spleen cells from the C3H/HeJ mouse were shown to be unable to respond to Fc fragments. The addition of adherent cells from either C3H/St or C3H/HeN mice to adherent cell depleted C3H/HeJ cells enabled them to respond to Fc, indicating the defect was in the adherent cell population.
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spelling pubmed-21856292008-04-17 The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells J Exp Med Articles The proliferative response of mouse B lymphocytes induced by Fc fragments was found to be dependent upon an adherent cell population. The adherent cell is esterase positive, irradiation resistant, and not susceptible to lysis by anti-thymus serum and complement. The mechanism(s) by which Fc fragments induce B-cell proliferation could be the result of the interaction of Fc with both B cells and adherent cells or with adherent cells which then release factors that trigger the B cells to proliferate. Spleen cells from the C3H/HeJ mouse were shown to be unable to respond to Fc fragments. The addition of adherent cells from either C3H/St or C3H/HeN mice to adherent cell depleted C3H/HeJ cells enabled them to respond to Fc, indicating the defect was in the adherent cell population. The Rockefeller University Press 1979-08-01 /pmc/articles/PMC2185629/ /pubmed/458375 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells
title The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells
title_full The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells
title_fullStr The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells
title_full_unstemmed The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells
title_short The requirement for adherent cells in the Fc fragment-induced proliferative response of murine spleen cells
title_sort requirement for adherent cells in the fc fragment-induced proliferative response of murine spleen cells
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185629/
https://www.ncbi.nlm.nih.gov/pubmed/458375

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