Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils

Incubation of [3H]arachidonic acid with the 17,000-g supernatant from homogenates of human neutrophils in the presence of indomethacin generated the unique metabolites 9-OH-5,7,11,14-eicosatetraenoic acid (9-HETE) and 8-HETE, in addition to 12-HETE, 11-HETE and 5-HETE. The human neutrophil chemotact...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185634/
https://www.ncbi.nlm.nih.gov/pubmed/458381
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collection PubMed
description Incubation of [3H]arachidonic acid with the 17,000-g supernatant from homogenates of human neutrophils in the presence of indomethacin generated the unique metabolites 9-OH-5,7,11,14-eicosatetraenoic acid (9-HETE) and 8-HETE, in addition to 12-HETE, 11-HETE and 5-HETE. The human neutrophil chemotactic activity of the HETE products exhibited a rank-order of potency with 5-HETE greater than 8-HETE = 9-HETE greater than 11-HETE = 12-HETE. The expression of chemokinetic activity as well as chemotactic activity suggested that the endogenous production of these principles may influence the mobility of human neutrophils.
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spelling pubmed-21856342008-04-17 Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils J Exp Med Articles Incubation of [3H]arachidonic acid with the 17,000-g supernatant from homogenates of human neutrophils in the presence of indomethacin generated the unique metabolites 9-OH-5,7,11,14-eicosatetraenoic acid (9-HETE) and 8-HETE, in addition to 12-HETE, 11-HETE and 5-HETE. The human neutrophil chemotactic activity of the HETE products exhibited a rank-order of potency with 5-HETE greater than 8-HETE = 9-HETE greater than 11-HETE = 12-HETE. The expression of chemokinetic activity as well as chemotactic activity suggested that the endogenous production of these principles may influence the mobility of human neutrophils. The Rockefeller University Press 1979-08-01 /pmc/articles/PMC2185634/ /pubmed/458381 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils
title Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils
title_full Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils
title_fullStr Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils
title_full_unstemmed Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils
title_short Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils
title_sort generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185634/
https://www.ncbi.nlm.nih.gov/pubmed/458381

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