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Site of binding of mouse IgG2b to the Fc receptor on mouse macrophages

Three mouse immunoglobulins with altered heavy chains have been used to study the specificity of the mouse IgG2b Fc receptor on mouse macrophages. These immunoglobulins were synthesized by variant clones derived from the MPC 11, IgG2b-producing mouse myeloma cell line. One variant, whose Fc receptor...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185652/
https://www.ncbi.nlm.nih.gov/pubmed/479765
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description Three mouse immunoglobulins with altered heavy chains have been used to study the specificity of the mouse IgG2b Fc receptor on mouse macrophages. These immunoglobulins were synthesized by variant clones derived from the MPC 11, IgG2b-producing mouse myeloma cell line. One variant, whose Fc receptor. A second variant, which makes a short heavy chain lacking the CH3 domain, binds specifically to the IgG2b Fc receptor. The third variant makes a hybrid IgG2b-IgG2a heavy chain whose CH3 domain is enterely IgG2a-like and binds to both IgG2a and IgG2b Fc receptors. These data suggest that the binding of mouse IgG2b immunoglobulins to the mouse macrophage Fc receptor involves a site within the CH2 domain and indicate that immunoglobulins with altered heavy chains are a useful tool to probe Fc receptors.
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spelling pubmed-21856522008-04-17 Site of binding of mouse IgG2b to the Fc receptor on mouse macrophages J Exp Med Articles Three mouse immunoglobulins with altered heavy chains have been used to study the specificity of the mouse IgG2b Fc receptor on mouse macrophages. These immunoglobulins were synthesized by variant clones derived from the MPC 11, IgG2b-producing mouse myeloma cell line. One variant, whose Fc receptor. A second variant, which makes a short heavy chain lacking the CH3 domain, binds specifically to the IgG2b Fc receptor. The third variant makes a hybrid IgG2b-IgG2a heavy chain whose CH3 domain is enterely IgG2a-like and binds to both IgG2a and IgG2b Fc receptors. These data suggest that the binding of mouse IgG2b immunoglobulins to the mouse macrophage Fc receptor involves a site within the CH2 domain and indicate that immunoglobulins with altered heavy chains are a useful tool to probe Fc receptors. The Rockefeller University Press 1979-09-19 /pmc/articles/PMC2185652/ /pubmed/479765 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Site of binding of mouse IgG2b to the Fc receptor on mouse macrophages
title Site of binding of mouse IgG2b to the Fc receptor on mouse macrophages
title_full Site of binding of mouse IgG2b to the Fc receptor on mouse macrophages
title_fullStr Site of binding of mouse IgG2b to the Fc receptor on mouse macrophages
title_full_unstemmed Site of binding of mouse IgG2b to the Fc receptor on mouse macrophages
title_short Site of binding of mouse IgG2b to the Fc receptor on mouse macrophages
title_sort site of binding of mouse igg2b to the fc receptor on mouse macrophages
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185652/
https://www.ncbi.nlm.nih.gov/pubmed/479765