Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses

The genetic requirements of carrier recognition were examined in the priming and elicitation of hapten specific, T-cell mediated, delayed- type hypersensitivity (DTH) responses. It was shown that nitrophenyl acetyl-poly-(L-glu56-L-lys35-L-phe9) (NP-GLO) could prime for NP responses only in strains o...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185691/
https://www.ncbi.nlm.nih.gov/pubmed/115960
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collection PubMed
description The genetic requirements of carrier recognition were examined in the priming and elicitation of hapten specific, T-cell mediated, delayed- type hypersensitivity (DTH) responses. It was shown that nitrophenyl acetyl-poly-(L-glu56-L-lys35-L-phe9) (NP-GLO) could prime for NP responses only in strains of mice which are Ir gene responders to GLO. In contrast to this requirement, NO-GLO could elicit an NP-specific response in NP-bovine gamma globulin primed mice, even in GLO nonresponder strains. Furthermore, the nonimmunogenic molecule, NP-GL, could elicit an NP-specific DTH response in animals primed with NP on an immunogenic carrier.
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spelling pubmed-21856912008-04-17 Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses J Exp Med Articles The genetic requirements of carrier recognition were examined in the priming and elicitation of hapten specific, T-cell mediated, delayed- type hypersensitivity (DTH) responses. It was shown that nitrophenyl acetyl-poly-(L-glu56-L-lys35-L-phe9) (NP-GLO) could prime for NP responses only in strains of mice which are Ir gene responders to GLO. In contrast to this requirement, NO-GLO could elicit an NP-specific response in NP-bovine gamma globulin primed mice, even in GLO nonresponder strains. Furthermore, the nonimmunogenic molecule, NP-GL, could elicit an NP-specific DTH response in animals primed with NP on an immunogenic carrier. The Rockefeller University Press 1979-11-01 /pmc/articles/PMC2185691/ /pubmed/115960 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses
title Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses
title_full Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses
title_fullStr Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses
title_full_unstemmed Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses
title_short Ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses
title_sort ir gene controlled carrier effects in the induction and elicitation of hapten-specific delayed-type hypersensitivity responses
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185691/
https://www.ncbi.nlm.nih.gov/pubmed/115960

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