Secretory component as the receptor for polymeric IgA on rat hepatocytes

Rat hepatocytes in short-term monolayer cultures bound radiolabeled polymeric rat IgA but not IgG. The binding of 125I-IgA was inhibited equally well by unlabeled polymeric IgA and by antiserum to rat secretory component (SC). The antibody to SC, after specific purification and radiolabeling, was bo...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185716/
https://www.ncbi.nlm.nih.gov/pubmed/512591
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collection PubMed
description Rat hepatocytes in short-term monolayer cultures bound radiolabeled polymeric rat IgA but not IgG. The binding of 125I-IgA was inhibited equally well by unlabeled polymeric IgA and by antiserum to rat secretory component (SC). The antibody to SC, after specific purification and radiolabeling, was bound to hepatocytes as effectively as the IgA. These results indicate that SC acts as the receptor for polymeric IgA on rat hepatocytes as it does on human gut epithelia, and that the transport of IgA from blood to bile in rats across the liver is analogous to that of IgA across human enterocytes.
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spelling pubmed-21857162008-04-17 Secretory component as the receptor for polymeric IgA on rat hepatocytes J Exp Med Articles Rat hepatocytes in short-term monolayer cultures bound radiolabeled polymeric rat IgA but not IgG. The binding of 125I-IgA was inhibited equally well by unlabeled polymeric IgA and by antiserum to rat secretory component (SC). The antibody to SC, after specific purification and radiolabeling, was bound to hepatocytes as effectively as the IgA. These results indicate that SC acts as the receptor for polymeric IgA on rat hepatocytes as it does on human gut epithelia, and that the transport of IgA from blood to bile in rats across the liver is analogous to that of IgA across human enterocytes. The Rockefeller University Press 1979-12-01 /pmc/articles/PMC2185716/ /pubmed/512591 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Secretory component as the receptor for polymeric IgA on rat hepatocytes
title Secretory component as the receptor for polymeric IgA on rat hepatocytes
title_full Secretory component as the receptor for polymeric IgA on rat hepatocytes
title_fullStr Secretory component as the receptor for polymeric IgA on rat hepatocytes
title_full_unstemmed Secretory component as the receptor for polymeric IgA on rat hepatocytes
title_short Secretory component as the receptor for polymeric IgA on rat hepatocytes
title_sort secretory component as the receptor for polymeric iga on rat hepatocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185716/
https://www.ncbi.nlm.nih.gov/pubmed/512591

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