Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras

The mechanism of restriction of T-cell specificity by the genotype of the thymus in allogeneic and semiallogeneic chimeras was investigated. Lack of induction of delayed-type hypersensitivity (DTH) directed against antigen in association with the nonthymic parental haplotype in naive cells adoptivel...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1980
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185764/
https://www.ncbi.nlm.nih.gov/pubmed/6965308
_version_ 1782145814423928832
collection PubMed
description The mechanism of restriction of T-cell specificity by the genotype of the thymus in allogeneic and semiallogeneic chimeras was investigated. Lack of induction of delayed-type hypersensitivity (DTH) directed against antigen in association with the nonthymic parental haplotype in naive cells adoptively transferred into chimeras suggests the existence of an in vivo suppressive mechanism. However, it was not possible to suppress the expression of DTH in sensitized cells transferred into chimeras, or to transfer this suppression to normal naive recipients.
format Text
id pubmed-2185764
institution National Center for Biotechnology Information
language English
publishDate 1980
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21857642008-04-17 Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras J Exp Med Articles The mechanism of restriction of T-cell specificity by the genotype of the thymus in allogeneic and semiallogeneic chimeras was investigated. Lack of induction of delayed-type hypersensitivity (DTH) directed against antigen in association with the nonthymic parental haplotype in naive cells adoptively transferred into chimeras suggests the existence of an in vivo suppressive mechanism. However, it was not possible to suppress the expression of DTH in sensitized cells transferred into chimeras, or to transfer this suppression to normal naive recipients. The Rockefeller University Press 1980-01-01 /pmc/articles/PMC2185764/ /pubmed/6965308 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras
title Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras
title_full Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras
title_fullStr Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras
title_full_unstemmed Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras
title_short Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras
title_sort suppression of t cells specific for the nonthymic parental h-2 haplotype in thymus-grafted chimeras
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185764/
https://www.ncbi.nlm.nih.gov/pubmed/6965308

Ejemplares similares