Low molecular weight iron-binding factor from mammalian tissue that potentiates bacterial growth

A low molecular weight, iron-binding factor was isolated from horse liver. This host-associated iron transfer factor (HAITF) is capable of binding iron and stimulating bacterial growth by promoting iron uptake into bacteria. Also, when injected into infected animals, HAITF increases the virulence of...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1980
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185783/
https://www.ncbi.nlm.nih.gov/pubmed/6985950
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collection PubMed
description A low molecular weight, iron-binding factor was isolated from horse liver. This host-associated iron transfer factor (HAITF) is capable of binding iron and stimulating bacterial growth by promoting iron uptake into bacteria. Also, when injected into infected animals, HAITF increases the virulence of bacterial infections. HAITF bioactivity is ubiquitous in animal tissues and present in serum. It is proposed that HAITF is a factor that inadvertently plays a role in the host-parasite competition for iron.
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spelling pubmed-21857832008-04-17 Low molecular weight iron-binding factor from mammalian tissue that potentiates bacterial growth J Exp Med Articles A low molecular weight, iron-binding factor was isolated from horse liver. This host-associated iron transfer factor (HAITF) is capable of binding iron and stimulating bacterial growth by promoting iron uptake into bacteria. Also, when injected into infected animals, HAITF increases the virulence of bacterial infections. HAITF bioactivity is ubiquitous in animal tissues and present in serum. It is proposed that HAITF is a factor that inadvertently plays a role in the host-parasite competition for iron. The Rockefeller University Press 1980-02-01 /pmc/articles/PMC2185783/ /pubmed/6985950 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Low molecular weight iron-binding factor from mammalian tissue that potentiates bacterial growth
title Low molecular weight iron-binding factor from mammalian tissue that potentiates bacterial growth
title_full Low molecular weight iron-binding factor from mammalian tissue that potentiates bacterial growth
title_fullStr Low molecular weight iron-binding factor from mammalian tissue that potentiates bacterial growth
title_full_unstemmed Low molecular weight iron-binding factor from mammalian tissue that potentiates bacterial growth
title_short Low molecular weight iron-binding factor from mammalian tissue that potentiates bacterial growth
title_sort low molecular weight iron-binding factor from mammalian tissue that potentiates bacterial growth
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185783/
https://www.ncbi.nlm.nih.gov/pubmed/6985950

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