Serological and biochemical identification of hybrid Ia antigens

Ia specificities 22 and 23 were found to be determinants on hybrid Ia molecules by serological and biochemical studies. Lipopolysaccharide- stimulated splenic lymphocytes from (B10 X B10.D2)F1 expressed Ia.22 although both the parents were negative. Similarly [D2.GD X B10.A(5R)]F1 cells expressed Ia...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1980
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185812/
https://www.ncbi.nlm.nih.gov/pubmed/7359084
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collection PubMed
description Ia specificities 22 and 23 were found to be determinants on hybrid Ia molecules by serological and biochemical studies. Lipopolysaccharide- stimulated splenic lymphocytes from (B10 X B10.D2)F1 expressed Ia.22 although both the parents were negative. Similarly [D2.GD X B10.A(5R)]F1 cells expressed Ia.23, whereas D2.GD and B10.A(5R) lacked it. Ia.22 can be generated by gene complementation of Ak-Ek, Ab-Ed, Ab- Ek, As-Ed, and As-Ek, whereas Ia.23 can be generated by Ad-Ed, Ad-Ek, and Ad-Ep. Other possible complementing combinations are under study. The role of Ia.22 and 23 in mixed lymphocyte reactions and immune responses are discussed.
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spelling pubmed-21858122008-04-17 Serological and biochemical identification of hybrid Ia antigens J Exp Med Articles Ia specificities 22 and 23 were found to be determinants on hybrid Ia molecules by serological and biochemical studies. Lipopolysaccharide- stimulated splenic lymphocytes from (B10 X B10.D2)F1 expressed Ia.22 although both the parents were negative. Similarly [D2.GD X B10.A(5R)]F1 cells expressed Ia.23, whereas D2.GD and B10.A(5R) lacked it. Ia.22 can be generated by gene complementation of Ak-Ek, Ab-Ed, Ab- Ek, As-Ed, and As-Ek, whereas Ia.23 can be generated by Ad-Ed, Ad-Ek, and Ad-Ep. Other possible complementing combinations are under study. The role of Ia.22 and 23 in mixed lymphocyte reactions and immune responses are discussed. The Rockefeller University Press 1980-03-01 /pmc/articles/PMC2185812/ /pubmed/7359084 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Serological and biochemical identification of hybrid Ia antigens
title Serological and biochemical identification of hybrid Ia antigens
title_full Serological and biochemical identification of hybrid Ia antigens
title_fullStr Serological and biochemical identification of hybrid Ia antigens
title_full_unstemmed Serological and biochemical identification of hybrid Ia antigens
title_short Serological and biochemical identification of hybrid Ia antigens
title_sort serological and biochemical identification of hybrid ia antigens
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185812/
https://www.ncbi.nlm.nih.gov/pubmed/7359084

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