Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor

Cellular events mediated by antigen-specific soluble factor extracted from carrier-primed suppressor T cells (TsF) in the suppressive interaction was studied. Keyhole limpet hemocyanin (KLH)-specific TsF directly acts on KLH-primed, I-J positive, nylon-wool-adherent T cells that have an acceptor sit...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1980
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185813/
https://www.ncbi.nlm.nih.gov/pubmed/6766980
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collection PubMed
description Cellular events mediated by antigen-specific soluble factor extracted from carrier-primed suppressor T cells (TsF) in the suppressive interaction was studied. Keyhole limpet hemocyanin (KLH)-specific TsF directly acts on KLH-primed, I-J positive, nylon-wool-adherent T cells that have an acceptor site for TsF. The nylon-wool-adherent T cells, after accepting TsF in the presence of specific antigen, generate new suppressor T cells acting as an actual effector cell type. Antigen- specificity and syngeneity at I-J between TsF and acceptor T cells are both required for the induction of new suppressor T cells. Newly induced suppressor T cells, however, suppress both syngeneic and allogeneic responses in an antigen-nonspecific fashion.
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spelling pubmed-21858132008-04-17 Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor J Exp Med Articles Cellular events mediated by antigen-specific soluble factor extracted from carrier-primed suppressor T cells (TsF) in the suppressive interaction was studied. Keyhole limpet hemocyanin (KLH)-specific TsF directly acts on KLH-primed, I-J positive, nylon-wool-adherent T cells that have an acceptor site for TsF. The nylon-wool-adherent T cells, after accepting TsF in the presence of specific antigen, generate new suppressor T cells acting as an actual effector cell type. Antigen- specificity and syngeneity at I-J between TsF and acceptor T cells are both required for the induction of new suppressor T cells. Newly induced suppressor T cells, however, suppress both syngeneic and allogeneic responses in an antigen-nonspecific fashion. The Rockefeller University Press 1980-03-01 /pmc/articles/PMC2185813/ /pubmed/6766980 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor
title Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor
title_full Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor
title_fullStr Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor
title_full_unstemmed Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor
title_short Cellular consequences in the suppression of antibody response by the antigen-specific T-cell factor
title_sort cellular consequences in the suppression of antibody response by the antigen-specific t-cell factor
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185813/
https://www.ncbi.nlm.nih.gov/pubmed/6766980

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