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Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison
Human T cell subpopulations have been defined on the basis of differential expression of either Fc receptors or specific cell-surface antigens. In this study, we utilized a series of monoclonal antibodies reactive with T cells, monocytes, and Ia antigens to characterize isolated subpopulations of T...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1980
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185839/ https://www.ncbi.nlm.nih.gov/pubmed/6445397 |
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collection | PubMed |
description | Human T cell subpopulations have been defined on the basis of differential expression of either Fc receptors or specific cell-surface antigens. In this study, we utilized a series of monoclonal antibodies reactive with T cells, monocytes, and Ia antigens to characterize isolated subpopulations of T cells bearing receptors for the Fc portion of IgG (T gamma) and subpopulations of T cells bearing receptors for the Fc portion of IgM T mu. The results showed that the T mu population contained both inducer (OKT4+) and cytotoxic/suppressor (OKT5+) populations and was similar to the unfractionated T cell population, whereas the T gamma subset contained few T lymphocytes (OKT3+) and was not enriched for either T cell subset defined by these monoclonal antibodies. Rather, the T gamma population was comprised largely of Ia- cells possessing a monocyte antigen (OKM1+). In reciprocal studies, it was found that both isolated OKT4+ and OKT5+ T cell subsets contained few T gamma cells, whereas both subsets were mainly comprised of T mu cells. We conclude that there is little correlation between T cell subsets defined by these monoclonal antibodies and those defined by Fc receptors. |
format | Text |
id | pubmed-2185839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1980 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21858392008-04-17 Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison J Exp Med Articles Human T cell subpopulations have been defined on the basis of differential expression of either Fc receptors or specific cell-surface antigens. In this study, we utilized a series of monoclonal antibodies reactive with T cells, monocytes, and Ia antigens to characterize isolated subpopulations of T cells bearing receptors for the Fc portion of IgG (T gamma) and subpopulations of T cells bearing receptors for the Fc portion of IgM T mu. The results showed that the T mu population contained both inducer (OKT4+) and cytotoxic/suppressor (OKT5+) populations and was similar to the unfractionated T cell population, whereas the T gamma subset contained few T lymphocytes (OKT3+) and was not enriched for either T cell subset defined by these monoclonal antibodies. Rather, the T gamma population was comprised largely of Ia- cells possessing a monocyte antigen (OKM1+). In reciprocal studies, it was found that both isolated OKT4+ and OKT5+ T cell subsets contained few T gamma cells, whereas both subsets were mainly comprised of T mu cells. We conclude that there is little correlation between T cell subsets defined by these monoclonal antibodies and those defined by Fc receptors. The Rockefeller University Press 1980-04-01 /pmc/articles/PMC2185839/ /pubmed/6445397 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison |
title | Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison |
title_full | Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison |
title_fullStr | Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison |
title_full_unstemmed | Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison |
title_short | Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison |
title_sort | human t lymphocyte subpopulations defined by fc receptors and monoclonal antibodies. a comparison |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185839/ https://www.ncbi.nlm.nih.gov/pubmed/6445397 |