Different divalent cation requirements for binding IgM complexes to lymphocytes and macrophages

We have found that Mg++ supports IgM complex binding to mouse lymphocytes but not to macrophages. In contrast, Ca++ supports IgM complex binding to macrophages but not lymphocytes. IgG complex binding to both lymphocytes and macrophages is divalent cation independent. These findings allow one to dis...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1980
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185888/
https://www.ncbi.nlm.nih.gov/pubmed/7381365
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collection PubMed
description We have found that Mg++ supports IgM complex binding to mouse lymphocytes but not to macrophages. In contrast, Ca++ supports IgM complex binding to macrophages but not lymphocytes. IgG complex binding to both lymphocytes and macrophages is divalent cation independent. These findings allow one to distinguish IgG from IgM binding and macrophage from lymphocyte IgM complex binding by their differential divalent cation requirements.
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spelling pubmed-21858882008-04-17 Different divalent cation requirements for binding IgM complexes to lymphocytes and macrophages J Exp Med Articles We have found that Mg++ supports IgM complex binding to mouse lymphocytes but not to macrophages. In contrast, Ca++ supports IgM complex binding to macrophages but not lymphocytes. IgG complex binding to both lymphocytes and macrophages is divalent cation independent. These findings allow one to distinguish IgG from IgM binding and macrophage from lymphocyte IgM complex binding by their differential divalent cation requirements. The Rockefeller University Press 1980-06-01 /pmc/articles/PMC2185888/ /pubmed/7381365 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Different divalent cation requirements for binding IgM complexes to lymphocytes and macrophages
title Different divalent cation requirements for binding IgM complexes to lymphocytes and macrophages
title_full Different divalent cation requirements for binding IgM complexes to lymphocytes and macrophages
title_fullStr Different divalent cation requirements for binding IgM complexes to lymphocytes and macrophages
title_full_unstemmed Different divalent cation requirements for binding IgM complexes to lymphocytes and macrophages
title_short Different divalent cation requirements for binding IgM complexes to lymphocytes and macrophages
title_sort different divalent cation requirements for binding igm complexes to lymphocytes and macrophages
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185888/
https://www.ncbi.nlm.nih.gov/pubmed/7381365

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