Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments

Fc fragments derived from human and murine Ig were found to be potent adjuvants when administered with antigen. Both the in vivo and in vitro anti- sheep erythrocytes (SRBC) responses were significantly enhanced by Fc fragments. The adjuvant effect was shown to be extremely dependent upon the dose o...

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Detalles Bibliográficos
Autores principales: Morgan, EL, Walker, SM, Thoman, ML, Weigle, WO
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1980
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185893/
https://www.ncbi.nlm.nih.gov/pubmed/7400754
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author Morgan, EL
Walker, SM
Thoman, ML
Weigle, WO
author_facet Morgan, EL
Walker, SM
Thoman, ML
Weigle, WO
author_sort Morgan, EL
collection PubMed
description Fc fragments derived from human and murine Ig were found to be potent adjuvants when administered with antigen. Both the in vivo and in vitro anti- sheep erythrocytes (SRBC) responses were significantly enhanced by Fc fragments. The adjuvant effect was shown to be extremely dependent upon the dose of antigen used, with the greatest enhancement occurring when suboptimal doses of antigen are employed. The anti-genicity of the Fc molecule was not related to its adjuvanticity because homologous Fc was as potent an adjuvant as heterologous Fc. Moreover, human Fc fragments enhanced anti-SRBC responses in mice which were tolerant to human gamma globulin.
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spelling pubmed-21858932008-04-17 Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments Morgan, EL Walker, SM Thoman, ML Weigle, WO J Exp Med Articles Fc fragments derived from human and murine Ig were found to be potent adjuvants when administered with antigen. Both the in vivo and in vitro anti- sheep erythrocytes (SRBC) responses were significantly enhanced by Fc fragments. The adjuvant effect was shown to be extremely dependent upon the dose of antigen used, with the greatest enhancement occurring when suboptimal doses of antigen are employed. The anti-genicity of the Fc molecule was not related to its adjuvanticity because homologous Fc was as potent an adjuvant as heterologous Fc. Moreover, human Fc fragments enhanced anti-SRBC responses in mice which were tolerant to human gamma globulin. The Rockefeller University Press 1980-07-01 /pmc/articles/PMC2185893/ /pubmed/7400754 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Morgan, EL
Walker, SM
Thoman, ML
Weigle, WO
Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments
title Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments
title_full Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments
title_fullStr Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments
title_full_unstemmed Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments
title_short Regulation of the immune response. I. The potentiation of in vivo and in vitro immune responses by Fc fragments
title_sort regulation of the immune response. i. the potentiation of in vivo and in vitro immune responses by fc fragments
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185893/
https://www.ncbi.nlm.nih.gov/pubmed/7400754
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AT weiglewo regulationoftheimmuneresponseithepotentiationofinvivoandinvitroimmuneresponsesbyfcfragments

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