Clonal nature of the immune response. II. The effect of immunization on clonal commitment

An inbred strain can produce several hundred different anti-group A carbohydrate (GAC) antibodies, as analyzed by isoelectric focusing. However, each individual mouse produces the bulk of its anti-GAC antibody as only one or two different spectrotypes, which appear to be randomly chosen. By using ad...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1980
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185905/
https://www.ncbi.nlm.nih.gov/pubmed/6995551
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collection PubMed
description An inbred strain can produce several hundred different anti-group A carbohydrate (GAC) antibodies, as analyzed by isoelectric focusing. However, each individual mouse produces the bulk of its anti-GAC antibody as only one or two different spectrotypes, which appear to be randomly chosen. By using adoptive transfer techniques, we have observed that clonal commitment occurs very early in immunization, sometimes even before immunization, and thus does not result from competition among B cells for antigen. X
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spelling pubmed-21859052008-04-17 Clonal nature of the immune response. II. The effect of immunization on clonal commitment J Exp Med Articles An inbred strain can produce several hundred different anti-group A carbohydrate (GAC) antibodies, as analyzed by isoelectric focusing. However, each individual mouse produces the bulk of its anti-GAC antibody as only one or two different spectrotypes, which appear to be randomly chosen. By using adoptive transfer techniques, we have observed that clonal commitment occurs very early in immunization, sometimes even before immunization, and thus does not result from competition among B cells for antigen. X The Rockefeller University Press 1980-07-01 /pmc/articles/PMC2185905/ /pubmed/6995551 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Clonal nature of the immune response. II. The effect of immunization on clonal commitment
title Clonal nature of the immune response. II. The effect of immunization on clonal commitment
title_full Clonal nature of the immune response. II. The effect of immunization on clonal commitment
title_fullStr Clonal nature of the immune response. II. The effect of immunization on clonal commitment
title_full_unstemmed Clonal nature of the immune response. II. The effect of immunization on clonal commitment
title_short Clonal nature of the immune response. II. The effect of immunization on clonal commitment
title_sort clonal nature of the immune response. ii. the effect of immunization on clonal commitment
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185905/
https://www.ncbi.nlm.nih.gov/pubmed/6995551

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