Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains

A single mendelian gene was identified for induction of the endogenous xenotropic murine leukemia virus in five mouse strains (C57BL/10, C57L, C57BR, AKR, and BALB/c). This locus, designated Bxv-1, mapped to the same site on chromosome 1 in all strains: Id-1-Pep-3-[Bxv-1-Lp]. Thus, inducibility loci...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1980
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185909/
https://www.ncbi.nlm.nih.gov/pubmed/6249881
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collection PubMed
description A single mendelian gene was identified for induction of the endogenous xenotropic murine leukemia virus in five mouse strains (C57BL/10, C57L, C57BR, AKR, and BALB/c). This locus, designated Bxv-1, mapped to the same site on chromosome 1 in all strains: Id-1-Pep-3-[Bxv-1-Lp]. Thus, inducibility loci for xenotropic virus are more limited in number and chromosomal distribution than ecotropic inducibility loci. Virus expression in mice with Bxv-1 was induced by treatment of fibroblasts with 5-iododeoxyuridine or by exposure of spleen cells to a B cell mitogen, bacterial lipopolysaccharide. An analysis of the hamster X mouse somatic cell hybrids indicated that chromosome 1, alone, was sufficient for virus induction.
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spelling pubmed-21859092008-04-17 Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains J Exp Med Articles A single mendelian gene was identified for induction of the endogenous xenotropic murine leukemia virus in five mouse strains (C57BL/10, C57L, C57BR, AKR, and BALB/c). This locus, designated Bxv-1, mapped to the same site on chromosome 1 in all strains: Id-1-Pep-3-[Bxv-1-Lp]. Thus, inducibility loci for xenotropic virus are more limited in number and chromosomal distribution than ecotropic inducibility loci. Virus expression in mice with Bxv-1 was induced by treatment of fibroblasts with 5-iododeoxyuridine or by exposure of spleen cells to a B cell mitogen, bacterial lipopolysaccharide. An analysis of the hamster X mouse somatic cell hybrids indicated that chromosome 1, alone, was sufficient for virus induction. The Rockefeller University Press 1980-07-01 /pmc/articles/PMC2185909/ /pubmed/6249881 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains
title Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains
title_full Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains
title_fullStr Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains
title_full_unstemmed Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains
title_short Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains
title_sort genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185909/
https://www.ncbi.nlm.nih.gov/pubmed/6249881

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