Defective B cell tolerance in adult (NZB X MZW)F1 mice

Hapten-specific tolerance was induced in vitro by trinitrophenyl-human gamma globulin (TNP32HGG) to a comparable degree in B cells from adult autoimmune (NZB X NZW)F1 (B/W) mice and normal BDF1, CBA/J, and DBA/1J mice. When a lower epitope density tolerogen (TNP7HGG) was used, B/W mice were signific...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1980
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185913/
https://www.ncbi.nlm.nih.gov/pubmed/6157774
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collection PubMed
description Hapten-specific tolerance was induced in vitro by trinitrophenyl-human gamma globulin (TNP32HGG) to a comparable degree in B cells from adult autoimmune (NZB X NZW)F1 (B/W) mice and normal BDF1, CBA/J, and DBA/1J mice. When a lower epitope density tolerogen (TNP7HGG) was used, B/W mice were significantly less sensitive than normal mice to the induction of B cell tolerance. This finding of defective B cell tolerance in adult B/W mice is consistent with previous reports that document other B cell abnormalities that may relate to the expression of autoimmune disease.
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spelling pubmed-21859132008-04-17 Defective B cell tolerance in adult (NZB X MZW)F1 mice J Exp Med Articles Hapten-specific tolerance was induced in vitro by trinitrophenyl-human gamma globulin (TNP32HGG) to a comparable degree in B cells from adult autoimmune (NZB X NZW)F1 (B/W) mice and normal BDF1, CBA/J, and DBA/1J mice. When a lower epitope density tolerogen (TNP7HGG) was used, B/W mice were significantly less sensitive than normal mice to the induction of B cell tolerance. This finding of defective B cell tolerance in adult B/W mice is consistent with previous reports that document other B cell abnormalities that may relate to the expression of autoimmune disease. The Rockefeller University Press 1980-09-01 /pmc/articles/PMC2185913/ /pubmed/6157774 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Defective B cell tolerance in adult (NZB X MZW)F1 mice
title Defective B cell tolerance in adult (NZB X MZW)F1 mice
title_full Defective B cell tolerance in adult (NZB X MZW)F1 mice
title_fullStr Defective B cell tolerance in adult (NZB X MZW)F1 mice
title_full_unstemmed Defective B cell tolerance in adult (NZB X MZW)F1 mice
title_short Defective B cell tolerance in adult (NZB X MZW)F1 mice
title_sort defective b cell tolerance in adult (nzb x mzw)f1 mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185913/
https://www.ncbi.nlm.nih.gov/pubmed/6157774

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