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Unusual human lymphoma phenotype defined by monoclonal antibody
The phenotype of three large cell (histiocytic) lymphomas of man has been defined with convential lymphocyte surface marker techniques, a panel of monoclonal antisera of hybridoma derivation (Ortho Pharmaceutical Corp.), and the fluorescence microscope. Two tumors exhibited surface IgG of lambda lig...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1980
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185966/ https://www.ncbi.nlm.nih.gov/pubmed/6158547 |
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collection | PubMed |
description | The phenotype of three large cell (histiocytic) lymphomas of man has been defined with convential lymphocyte surface marker techniques, a panel of monoclonal antisera of hybridoma derivation (Ortho Pharmaceutical Corp.), and the fluorescence microscope. Two tumors exhibited surface IgG of lambda light-chain type, whereas the third was negative for surface Ig but contained the same Ig in the cytoplasm. With the monoclonal antisera, all three were found to bear two surface antigens (OKT9 and OKT10) previously described on early thymocytes, and were devoid of the Ia antigen. The available knowledge suggests that these neoplasms represent the expansion of a clone of B lymphocytes along the pathway that leads to plasma cell differentiation rather than a clone with both B and T surface membrane markers. |
format | Text |
id | pubmed-2185966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1980 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21859662008-04-17 Unusual human lymphoma phenotype defined by monoclonal antibody J Exp Med Articles The phenotype of three large cell (histiocytic) lymphomas of man has been defined with convential lymphocyte surface marker techniques, a panel of monoclonal antisera of hybridoma derivation (Ortho Pharmaceutical Corp.), and the fluorescence microscope. Two tumors exhibited surface IgG of lambda light-chain type, whereas the third was negative for surface Ig but contained the same Ig in the cytoplasm. With the monoclonal antisera, all three were found to bear two surface antigens (OKT9 and OKT10) previously described on early thymocytes, and were devoid of the Ia antigen. The available knowledge suggests that these neoplasms represent the expansion of a clone of B lymphocytes along the pathway that leads to plasma cell differentiation rather than a clone with both B and T surface membrane markers. The Rockefeller University Press 1980-10-01 /pmc/articles/PMC2185966/ /pubmed/6158547 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Unusual human lymphoma phenotype defined by monoclonal antibody |
title | Unusual human lymphoma phenotype defined by monoclonal antibody |
title_full | Unusual human lymphoma phenotype defined by monoclonal antibody |
title_fullStr | Unusual human lymphoma phenotype defined by monoclonal antibody |
title_full_unstemmed | Unusual human lymphoma phenotype defined by monoclonal antibody |
title_short | Unusual human lymphoma phenotype defined by monoclonal antibody |
title_sort | unusual human lymphoma phenotype defined by monoclonal antibody |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2185966/ https://www.ncbi.nlm.nih.gov/pubmed/6158547 |