Aberrant Ae (E beta) Ia polypeptide chain in H-2g2 haplotype mice. Possible result of an intragenic recombination or mutation

Mice of strains D2.GD and B10.GD, which carry the recombinant haplotype H-2g2 (previously typed as H-2Kd I-Ad / I-Bb I-Jb I-Eb I-Cb Sb H-2Db), have an Ae (E beta) polypeptide chain electrophoretically distinct from the Ae chains of both b and d haplotype mice, including the progenitor strains from w...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1980
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186011/
https://www.ncbi.nlm.nih.gov/pubmed/6933209
_version_ 1782145870494433280
collection PubMed
description Mice of strains D2.GD and B10.GD, which carry the recombinant haplotype H-2g2 (previously typed as H-2Kd I-Ad / I-Bb I-Jb I-Eb I-Cb Sb H-2Db), have an Ae (E beta) polypeptide chain electrophoretically distinct from the Ae chains of both b and d haplotype mice, including the progenitor strains from which the recombinant H-2g2 chromosome was derived. The evidence presented suggests that the altered molecular properties of the Aeg2 chain may be a consequence of an intragenic recombination event in the I-A subregion within the structural gene for this polypeptide chain. Because the A alpha and A beta chains controlled by H-2g2 appear to be d haplotype in origin, this finding would map the gene for Ae to the right of the loci controlling the A alpha and A beta chains
format Text
id pubmed-2186011
institution National Center for Biotechnology Information
language English
publishDate 1980
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21860112008-04-17 Aberrant Ae (E beta) Ia polypeptide chain in H-2g2 haplotype mice. Possible result of an intragenic recombination or mutation J Exp Med Articles Mice of strains D2.GD and B10.GD, which carry the recombinant haplotype H-2g2 (previously typed as H-2Kd I-Ad / I-Bb I-Jb I-Eb I-Cb Sb H-2Db), have an Ae (E beta) polypeptide chain electrophoretically distinct from the Ae chains of both b and d haplotype mice, including the progenitor strains from which the recombinant H-2g2 chromosome was derived. The evidence presented suggests that the altered molecular properties of the Aeg2 chain may be a consequence of an intragenic recombination event in the I-A subregion within the structural gene for this polypeptide chain. Because the A alpha and A beta chains controlled by H-2g2 appear to be d haplotype in origin, this finding would map the gene for Ae to the right of the loci controlling the A alpha and A beta chains The Rockefeller University Press 1980-11-01 /pmc/articles/PMC2186011/ /pubmed/6933209 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Aberrant Ae (E beta) Ia polypeptide chain in H-2g2 haplotype mice. Possible result of an intragenic recombination or mutation
title Aberrant Ae (E beta) Ia polypeptide chain in H-2g2 haplotype mice. Possible result of an intragenic recombination or mutation
title_full Aberrant Ae (E beta) Ia polypeptide chain in H-2g2 haplotype mice. Possible result of an intragenic recombination or mutation
title_fullStr Aberrant Ae (E beta) Ia polypeptide chain in H-2g2 haplotype mice. Possible result of an intragenic recombination or mutation
title_full_unstemmed Aberrant Ae (E beta) Ia polypeptide chain in H-2g2 haplotype mice. Possible result of an intragenic recombination or mutation
title_short Aberrant Ae (E beta) Ia polypeptide chain in H-2g2 haplotype mice. Possible result of an intragenic recombination or mutation
title_sort aberrant ae (e beta) ia polypeptide chain in h-2g2 haplotype mice. possible result of an intragenic recombination or mutation
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186011/
https://www.ncbi.nlm.nih.gov/pubmed/6933209

Ejemplares similares