Release of endogenous pyrogen-activating factor from concanavalin A- stimulated human lymphocytes

Evidence is presented that the mitogen concanavalin A stimulates human lymphocytes to produce a nonpyrogenic lymphokine (LK) that is capable of activating human monocytes but not granulocytes to produce endogenous pyrogen (EP) in vitro. The potency of this preparation should facilitate further studi...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1980
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186039/
https://www.ncbi.nlm.nih.gov/pubmed/7452151
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collection PubMed
description Evidence is presented that the mitogen concanavalin A stimulates human lymphocytes to produce a nonpyrogenic lymphokine (LK) that is capable of activating human monocytes but not granulocytes to produce endogenous pyrogen (EP) in vitro. The potency of this preparation should facilitate further studies to purify and characterize this agent and determine its relation to other know LK. It seems likely that this factor, which we have called EP-activating factor (EPAF), plays a significant role in the development of fever in states of delayed hypersensitivity in man.
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spelling pubmed-21860392008-04-17 Release of endogenous pyrogen-activating factor from concanavalin A- stimulated human lymphocytes J Exp Med Articles Evidence is presented that the mitogen concanavalin A stimulates human lymphocytes to produce a nonpyrogenic lymphokine (LK) that is capable of activating human monocytes but not granulocytes to produce endogenous pyrogen (EP) in vitro. The potency of this preparation should facilitate further studies to purify and characterize this agent and determine its relation to other know LK. It seems likely that this factor, which we have called EP-activating factor (EPAF), plays a significant role in the development of fever in states of delayed hypersensitivity in man. The Rockefeller University Press 1980-12-01 /pmc/articles/PMC2186039/ /pubmed/7452151 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Release of endogenous pyrogen-activating factor from concanavalin A- stimulated human lymphocytes
title Release of endogenous pyrogen-activating factor from concanavalin A- stimulated human lymphocytes
title_full Release of endogenous pyrogen-activating factor from concanavalin A- stimulated human lymphocytes
title_fullStr Release of endogenous pyrogen-activating factor from concanavalin A- stimulated human lymphocytes
title_full_unstemmed Release of endogenous pyrogen-activating factor from concanavalin A- stimulated human lymphocytes
title_short Release of endogenous pyrogen-activating factor from concanavalin A- stimulated human lymphocytes
title_sort release of endogenous pyrogen-activating factor from concanavalin a- stimulated human lymphocytes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186039/
https://www.ncbi.nlm.nih.gov/pubmed/7452151

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