A monoclonal antibody that recognizes B cells and B cell precursors in mice

The monoclonal antibody, RA3-2C2, appears to be specific for cells within the B cell lineage. This antibody does not recognize thymocytes, peripheral T cells, or nonlymphoid hematopoietic cells in the spleen or bone marrow. Nor does it recognize the pluripotent hematopoietic stem cells, the spleen c...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1981
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186081/
https://www.ncbi.nlm.nih.gov/pubmed/6787164
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description The monoclonal antibody, RA3-2C2, appears to be specific for cells within the B cell lineage. This antibody does not recognize thymocytes, peripheral T cells, or nonlymphoid hematopoietic cells in the spleen or bone marrow. Nor does it recognize the pluripotent hematopoietic stem cells, the spleen colony-forming unit, All sIg+ B cells and most plasma cells are RA3-2C2+. In addition, approximately 20% of nucleated bone marrow cells are RA3-2C2+ but sIg-. This population contains B cell precursors that can give rise to sIg+ cells within 2 d in vitro.
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spelling pubmed-21860812008-04-17 A monoclonal antibody that recognizes B cells and B cell precursors in mice J Exp Med Articles The monoclonal antibody, RA3-2C2, appears to be specific for cells within the B cell lineage. This antibody does not recognize thymocytes, peripheral T cells, or nonlymphoid hematopoietic cells in the spleen or bone marrow. Nor does it recognize the pluripotent hematopoietic stem cells, the spleen colony-forming unit, All sIg+ B cells and most plasma cells are RA3-2C2+. In addition, approximately 20% of nucleated bone marrow cells are RA3-2C2+ but sIg-. This population contains B cell precursors that can give rise to sIg+ cells within 2 d in vitro. The Rockefeller University Press 1981-02-01 /pmc/articles/PMC2186081/ /pubmed/6787164 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
A monoclonal antibody that recognizes B cells and B cell precursors in mice
title A monoclonal antibody that recognizes B cells and B cell precursors in mice
title_full A monoclonal antibody that recognizes B cells and B cell precursors in mice
title_fullStr A monoclonal antibody that recognizes B cells and B cell precursors in mice
title_full_unstemmed A monoclonal antibody that recognizes B cells and B cell precursors in mice
title_short A monoclonal antibody that recognizes B cells and B cell precursors in mice
title_sort monoclonal antibody that recognizes b cells and b cell precursors in mice
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186081/
https://www.ncbi.nlm.nih.gov/pubmed/6787164

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