Cargando…

In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus

Genetically resistant G3H mice routinely yielded macrophages that were resistant when grown in 90% horse serum. These mice also routinely yielded macrophages that were susceptible to the same virus, MHV (PRI), in vitro after the mice had been treated with three intraperitoneal doses, of hydrocortiso...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1981
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186118/
https://www.ncbi.nlm.nih.gov/pubmed/6265581
_version_ 1782145893167792128
collection PubMed
description Genetically resistant G3H mice routinely yielded macrophages that were resistant when grown in 90% horse serum. These mice also routinely yielded macrophages that were susceptible to the same virus, MHV (PRI), in vitro after the mice had been treated with three intraperitoneal doses, of hydrocortisone. Dexamethasone and prednisolone when similarly administered also increased the susceptibility of C3H macrophages taken from the treated animal, but progesterone and testosterone did not. In addition, spleen cells from mice treated with cortisone made the resistant C3H macrophages 100 times more susceptible in vitro. Increased in vitro susceptibility induced in this way by hydrocortisone was reversed by exposure to supernatant fluid removed from cultures of concanavalin A-treated spleen cells.
format Text
id pubmed-2186118
institution National Center for Biotechnology Information
language English
publishDate 1981
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21861182008-04-17 In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus J Exp Med Articles Genetically resistant G3H mice routinely yielded macrophages that were resistant when grown in 90% horse serum. These mice also routinely yielded macrophages that were susceptible to the same virus, MHV (PRI), in vitro after the mice had been treated with three intraperitoneal doses, of hydrocortisone. Dexamethasone and prednisolone when similarly administered also increased the susceptibility of C3H macrophages taken from the treated animal, but progesterone and testosterone did not. In addition, spleen cells from mice treated with cortisone made the resistant C3H macrophages 100 times more susceptible in vitro. Increased in vitro susceptibility induced in this way by hydrocortisone was reversed by exposure to supernatant fluid removed from cultures of concanavalin A-treated spleen cells. The Rockefeller University Press 1981-03-01 /pmc/articles/PMC2186118/ /pubmed/6265581 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus
title In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus
title_full In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus
title_fullStr In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus
title_full_unstemmed In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus
title_short In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus
title_sort in vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186118/
https://www.ncbi.nlm.nih.gov/pubmed/6265581