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In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus
Genetically resistant G3H mice routinely yielded macrophages that were resistant when grown in 90% horse serum. These mice also routinely yielded macrophages that were susceptible to the same virus, MHV (PRI), in vitro after the mice had been treated with three intraperitoneal doses, of hydrocortiso...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1981
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186118/ https://www.ncbi.nlm.nih.gov/pubmed/6265581 |
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collection | PubMed |
description | Genetically resistant G3H mice routinely yielded macrophages that were resistant when grown in 90% horse serum. These mice also routinely yielded macrophages that were susceptible to the same virus, MHV (PRI), in vitro after the mice had been treated with three intraperitoneal doses, of hydrocortisone. Dexamethasone and prednisolone when similarly administered also increased the susceptibility of C3H macrophages taken from the treated animal, but progesterone and testosterone did not. In addition, spleen cells from mice treated with cortisone made the resistant C3H macrophages 100 times more susceptible in vitro. Increased in vitro susceptibility induced in this way by hydrocortisone was reversed by exposure to supernatant fluid removed from cultures of concanavalin A-treated spleen cells. |
format | Text |
id | pubmed-2186118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1981 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-21861182008-04-17 In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus J Exp Med Articles Genetically resistant G3H mice routinely yielded macrophages that were resistant when grown in 90% horse serum. These mice also routinely yielded macrophages that were susceptible to the same virus, MHV (PRI), in vitro after the mice had been treated with three intraperitoneal doses, of hydrocortisone. Dexamethasone and prednisolone when similarly administered also increased the susceptibility of C3H macrophages taken from the treated animal, but progesterone and testosterone did not. In addition, spleen cells from mice treated with cortisone made the resistant C3H macrophages 100 times more susceptible in vitro. Increased in vitro susceptibility induced in this way by hydrocortisone was reversed by exposure to supernatant fluid removed from cultures of concanavalin A-treated spleen cells. The Rockefeller University Press 1981-03-01 /pmc/articles/PMC2186118/ /pubmed/6265581 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus |
title | In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus |
title_full | In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus |
title_fullStr | In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus |
title_full_unstemmed | In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus |
title_short | In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus |
title_sort | in vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186118/ https://www.ncbi.nlm.nih.gov/pubmed/6265581 |