Major histocompatibility complex restriction of soluble helper molecules in T cell responses to altered self

Evidence for major histocompatibility complex (MHC) restriction of soluble helper effects was observed in the generation of syngeneic killer T cells to trinitrophenyl-altered self. Ia-bearing T cells obscure the observation of such interactions, thus, must be removed to detect MHC restriction of non...

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Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1981
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186169/
https://www.ncbi.nlm.nih.gov/pubmed/6972996
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collection PubMed
description Evidence for major histocompatibility complex (MHC) restriction of soluble helper effects was observed in the generation of syngeneic killer T cells to trinitrophenyl-altered self. Ia-bearing T cells obscure the observation of such interactions, thus, must be removed to detect MHC restriction of nonspecific soluble helper factor supernates (HFS). Genetic mapping studies demonstrated that the strain producing HFS must be compatible in the H-21A region with the strain utilizing the helper molecules for optimal helper signals to be delivered.
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spelling pubmed-21861692008-04-17 Major histocompatibility complex restriction of soluble helper molecules in T cell responses to altered self J Exp Med Articles Evidence for major histocompatibility complex (MHC) restriction of soluble helper effects was observed in the generation of syngeneic killer T cells to trinitrophenyl-altered self. Ia-bearing T cells obscure the observation of such interactions, thus, must be removed to detect MHC restriction of nonspecific soluble helper factor supernates (HFS). Genetic mapping studies demonstrated that the strain producing HFS must be compatible in the H-21A region with the strain utilizing the helper molecules for optimal helper signals to be delivered. The Rockefeller University Press 1981-05-01 /pmc/articles/PMC2186169/ /pubmed/6972996 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Major histocompatibility complex restriction of soluble helper molecules in T cell responses to altered self
title Major histocompatibility complex restriction of soluble helper molecules in T cell responses to altered self
title_full Major histocompatibility complex restriction of soluble helper molecules in T cell responses to altered self
title_fullStr Major histocompatibility complex restriction of soluble helper molecules in T cell responses to altered self
title_full_unstemmed Major histocompatibility complex restriction of soluble helper molecules in T cell responses to altered self
title_short Major histocompatibility complex restriction of soluble helper molecules in T cell responses to altered self
title_sort major histocompatibility complex restriction of soluble helper molecules in t cell responses to altered self
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186169/
https://www.ncbi.nlm.nih.gov/pubmed/6972996

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