Bone marrow origin of Ia-positive cells in the medulla rat thymus

Irradiated rats were reconstituted with bone marrow from F1 hybrids. Ia antigen of donor-bone marrow origin was detected by an immunoperoxidase technique on cryostat sections and found predominantly in the medulla of rat thymus 2 wk after reconstitution. These Ia-bearing cells increased in number wi...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1981
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186196/
https://www.ncbi.nlm.nih.gov/pubmed/6942092
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collection PubMed
description Irradiated rats were reconstituted with bone marrow from F1 hybrids. Ia antigen of donor-bone marrow origin was detected by an immunoperoxidase technique on cryostat sections and found predominantly in the medulla of rat thymus 2 wk after reconstitution. These Ia-bearing cells increased in number with time after reconstitution, but the Ia on the cortical epithelial cells remained of host origin. The nature of the bone marrow-derived cells and their implication for major histocompatibility complex restriction are discussed.
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spelling pubmed-21861962008-04-17 Bone marrow origin of Ia-positive cells in the medulla rat thymus J Exp Med Articles Irradiated rats were reconstituted with bone marrow from F1 hybrids. Ia antigen of donor-bone marrow origin was detected by an immunoperoxidase technique on cryostat sections and found predominantly in the medulla of rat thymus 2 wk after reconstitution. These Ia-bearing cells increased in number with time after reconstitution, but the Ia on the cortical epithelial cells remained of host origin. The nature of the bone marrow-derived cells and their implication for major histocompatibility complex restriction are discussed. The Rockefeller University Press 1981-06-01 /pmc/articles/PMC2186196/ /pubmed/6942092 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Bone marrow origin of Ia-positive cells in the medulla rat thymus
title Bone marrow origin of Ia-positive cells in the medulla rat thymus
title_full Bone marrow origin of Ia-positive cells in the medulla rat thymus
title_fullStr Bone marrow origin of Ia-positive cells in the medulla rat thymus
title_full_unstemmed Bone marrow origin of Ia-positive cells in the medulla rat thymus
title_short Bone marrow origin of Ia-positive cells in the medulla rat thymus
title_sort bone marrow origin of ia-positive cells in the medulla rat thymus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186196/
https://www.ncbi.nlm.nih.gov/pubmed/6942092

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