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Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study

CONTEXT. -: Myeloid sarcoma (MS) is a neoplasm of immature granulocytes, monocytes, or both involving any extramedullary site. The correct diagnosis of MS is important for adequate therapy, which is often delayed because of a high misdiagnosis rate. OBJECTIVE. -: To evaluate the lineage differentiat...

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Autores principales: Alexiev, Borislav A, Wang, Wenle, Ning, Yi, Chumsri, Saranya, Gojo, Ivana, Rodgers, William H, Stass, Sanford A, Zhao, Xianfeng F
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186303/
https://www.ncbi.nlm.nih.gov/pubmed/17974004
http://dx.doi.org/10.1186/1746-1596-2-42
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author Alexiev, Borislav A
Wang, Wenle
Ning, Yi
Chumsri, Saranya
Gojo, Ivana
Rodgers, William H
Stass, Sanford A
Zhao, Xianfeng F
author_facet Alexiev, Borislav A
Wang, Wenle
Ning, Yi
Chumsri, Saranya
Gojo, Ivana
Rodgers, William H
Stass, Sanford A
Zhao, Xianfeng F
author_sort Alexiev, Borislav A
collection PubMed
description CONTEXT. -: Myeloid sarcoma (MS) is a neoplasm of immature granulocytes, monocytes, or both involving any extramedullary site. The correct diagnosis of MS is important for adequate therapy, which is often delayed because of a high misdiagnosis rate. OBJECTIVE. -: To evaluate the lineage differentiation of neoplastic cells in MS by immunohistochemistry, and to correlate the results with clinicopathologic findings and cytogenetic studies. DESIGN. -: Histologic and immunohistochemical examinations were performed on formalin-fixed paraffin-embedded tissue samples from 13 cases of MS. They were classified according to the World Health Organization criteria. Chromosomal analysis data were available in 11 cases. Clinical, pathological, and cytogenetic findings were analyzed. RESULTS. -: The study included six male and seven female patients with an age range of 25 to 72 years (mean, 49.3 years) and a male to female ratio of 1:1.2. MS de novo occurred in 4/13 (31%) of cases examined. The most sensitive immunohistochemical markers were CD43 and lysozyme present in all cases with MS (13/13, 100%). All de novo MS showed a normal karyotype, monoblastic differentiation, and lack of CD34. The most common chromosomal abnormalities in MS associated with a hematopoietic disorder were trisomy 8 and inv(16) (2/11, 18%). CONCLUSION. -: An immunohistochemical panel including CD43, lysozyme, myeloperoxidase (MPO), CD68 (or CD163), CD117, CD3 and CD20 can successfully identify the vast majority of MS variants in formalin-fixed paraffin-embedded tissue sections. The present report expands the spectrum of our knowledge showing that de novo MS has frequent monoblastic differentiation and frequently carries a normal karyotype.
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spelling pubmed-21863032008-01-10 Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study Alexiev, Borislav A Wang, Wenle Ning, Yi Chumsri, Saranya Gojo, Ivana Rodgers, William H Stass, Sanford A Zhao, Xianfeng F Diagn Pathol Research CONTEXT. -: Myeloid sarcoma (MS) is a neoplasm of immature granulocytes, monocytes, or both involving any extramedullary site. The correct diagnosis of MS is important for adequate therapy, which is often delayed because of a high misdiagnosis rate. OBJECTIVE. -: To evaluate the lineage differentiation of neoplastic cells in MS by immunohistochemistry, and to correlate the results with clinicopathologic findings and cytogenetic studies. DESIGN. -: Histologic and immunohistochemical examinations were performed on formalin-fixed paraffin-embedded tissue samples from 13 cases of MS. They were classified according to the World Health Organization criteria. Chromosomal analysis data were available in 11 cases. Clinical, pathological, and cytogenetic findings were analyzed. RESULTS. -: The study included six male and seven female patients with an age range of 25 to 72 years (mean, 49.3 years) and a male to female ratio of 1:1.2. MS de novo occurred in 4/13 (31%) of cases examined. The most sensitive immunohistochemical markers were CD43 and lysozyme present in all cases with MS (13/13, 100%). All de novo MS showed a normal karyotype, monoblastic differentiation, and lack of CD34. The most common chromosomal abnormalities in MS associated with a hematopoietic disorder were trisomy 8 and inv(16) (2/11, 18%). CONCLUSION. -: An immunohistochemical panel including CD43, lysozyme, myeloperoxidase (MPO), CD68 (or CD163), CD117, CD3 and CD20 can successfully identify the vast majority of MS variants in formalin-fixed paraffin-embedded tissue sections. The present report expands the spectrum of our knowledge showing that de novo MS has frequent monoblastic differentiation and frequently carries a normal karyotype. BioMed Central 2007-10-31 /pmc/articles/PMC2186303/ /pubmed/17974004 http://dx.doi.org/10.1186/1746-1596-2-42 Text en Copyright © 2007 Alexiev et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Alexiev, Borislav A
Wang, Wenle
Ning, Yi
Chumsri, Saranya
Gojo, Ivana
Rodgers, William H
Stass, Sanford A
Zhao, Xianfeng F
Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study
title Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study
title_full Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study
title_fullStr Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study
title_full_unstemmed Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study
title_short Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study
title_sort myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186303/
https://www.ncbi.nlm.nih.gov/pubmed/17974004
http://dx.doi.org/10.1186/1746-1596-2-42
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