Safety and Immunogenicity of an AMA-1 Malaria Vaccine in Malian Adults: Results of a Phase 1 Randomized Controlled Trial

BACKGROUND: The objective was to evaluate the safety, reactogenicity and immunogenicity of the AMA-1-based blood-stage malaria vaccine FMP2.1/AS02A in adults exposed to seasonal malaria. METHODOLOGY/PRINCIPAL FINDINGS: A phase 1 double blind randomized controlled dose escalation trial was conducted...

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Detalles Bibliográficos
Autores principales: Thera, Mahamadou A., Doumbo, Ogobara K., Coulibaly, Drissa, Diallo, Dapa A., Kone, Abdoulaye K., Guindo, Ando B., Traore, Karim, Dicko, Alassane, Sagara, Issaka, Sissoko, Mahamadou S., Baby, Mounirou, Sissoko, Mady, Diarra, Issa, Niangaly, Amadou, Dolo, Amagana, Daou, Modibo, Diawara, Sory I., Heppner, D. Gray, Stewart, V. Ann, Angov, Evelina, Bergmann-Leitner, Elke S., Lanar, David E., Dutta, Sheetij, Soisson, Lorraine, Diggs, Carter L., Leach, Amanda, Owusu, Alex, Dubois, Marie-Claude, Cohen, Joe, Nixon, Jason N., Gregson, Aric, Takala, Shannon L., Lyke, Kirsten E., Plowe, Christopher V.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186380/
https://www.ncbi.nlm.nih.gov/pubmed/18213374
http://dx.doi.org/10.1371/journal.pone.0001465

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