Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen

Outbred Wistar rats immunized with native type II collagen developed ear lesions resembling those of human relapsing chondritis. As in human disease, these lesions were characterized by intense chondritis, positive immunofluorescence reactions to IgG and C3, and circulating IgG reactive with native...

Descripción completa

Detalles Bibliográficos
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1981
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186432/
https://www.ncbi.nlm.nih.gov/pubmed/7021752
_version_ 1782145940126171136
collection PubMed
description Outbred Wistar rats immunized with native type II collagen developed ear lesions resembling those of human relapsing chondritis. As in human disease, these lesions were characterized by intense chondritis, positive immunofluorescence reactions to IgG and C3, and circulating IgG reactive with native type II collagen. Furthermore, electron-dense deposits were seen near the surface of chondrocytes and corresponded with deposits of IgG and C3. These observations suggest a causal relation between humoral immunity to type II collagen and auricular chondritis in the rat and support the hypothesis than human relapsing polychondritis is an autoimmune disease mediated by immunity to type II collagen.
format Text
id pubmed-2186432
institution National Center for Biotechnology Information
language English
publishDate 1981
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-21864322008-04-17 Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen J Exp Med Articles Outbred Wistar rats immunized with native type II collagen developed ear lesions resembling those of human relapsing chondritis. As in human disease, these lesions were characterized by intense chondritis, positive immunofluorescence reactions to IgG and C3, and circulating IgG reactive with native type II collagen. Furthermore, electron-dense deposits were seen near the surface of chondrocytes and corresponded with deposits of IgG and C3. These observations suggest a causal relation between humoral immunity to type II collagen and auricular chondritis in the rat and support the hypothesis than human relapsing polychondritis is an autoimmune disease mediated by immunity to type II collagen. The Rockefeller University Press 1981-08-01 /pmc/articles/PMC2186432/ /pubmed/7021752 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen
title Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen
title_full Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen
title_fullStr Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen
title_full_unstemmed Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen
title_short Auricular chondritis in rats. An experimental model of relapsing polychondritis induced with type II collagen
title_sort auricular chondritis in rats. an experimental model of relapsing polychondritis induced with type ii collagen
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186432/
https://www.ncbi.nlm.nih.gov/pubmed/7021752

Ejemplares similares