Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states

In limiting dilution analysis, the absolute frequencies of lipopolysaccharide-reactive B cell precursors producing anti- trinitrophenyl antibodies or the MOPC460 idiotype were studied in BALB/c mice, either normal, or immunized with antigen (Ab1), the idiotype (Ab2), or a monoclonal anti-idiotype an...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1981
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186433/
https://www.ncbi.nlm.nih.gov/pubmed/6973609
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collection PubMed
description In limiting dilution analysis, the absolute frequencies of lipopolysaccharide-reactive B cell precursors producing anti- trinitrophenyl antibodies or the MOPC460 idiotype were studied in BALB/c mice, either normal, or immunized with antigen (Ab1), the idiotype (Ab2), or a monoclonal anti-idiotype antibody (Ab3). Anti- idiotype immunity results in the suppression of the B cell precursors for the relevant idiotype, and anti-(anti-idiotype) immunity leads to a 10-fold increase in precursor B cell frequencies, with a comparatively lower increase in antibody-producing precursors. The findings can only be explained by variations in the composition of the B cell compartment in the various immune states.
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spelling pubmed-21864332008-04-17 Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states J Exp Med Articles In limiting dilution analysis, the absolute frequencies of lipopolysaccharide-reactive B cell precursors producing anti- trinitrophenyl antibodies or the MOPC460 idiotype were studied in BALB/c mice, either normal, or immunized with antigen (Ab1), the idiotype (Ab2), or a monoclonal anti-idiotype antibody (Ab3). Anti- idiotype immunity results in the suppression of the B cell precursors for the relevant idiotype, and anti-(anti-idiotype) immunity leads to a 10-fold increase in precursor B cell frequencies, with a comparatively lower increase in antibody-producing precursors. The findings can only be explained by variations in the composition of the B cell compartment in the various immune states. The Rockefeller University Press 1981-08-01 /pmc/articles/PMC2186433/ /pubmed/6973609 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states
title Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states
title_full Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states
title_fullStr Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states
title_full_unstemmed Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states
title_short Immune networks. Frequencies of antibody- and idiotype-producing B cell clones in various steady states
title_sort immune networks. frequencies of antibody- and idiotype-producing b cell clones in various steady states
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186433/
https://www.ncbi.nlm.nih.gov/pubmed/6973609

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